Differentiation of lymphomatous, metastatic, and non-malignant lymphadenopathy in the neck with quantitative diffusion-weighted imaging: systematic review and meta-analysis.
Purpose: To perform a systematic review and meta-analysis of literature comparing average apparent diffusion coefficient (ADC) for differentiating lymphomatous, metastatic, and non-malignant cervical lymphadenopathy. Methods: We performed a comprehensive literature search of Ovid MEDLINE, EMBASE, Co...
| Publicado en: | Neuroradiology Vol. 61; no. 8; pp. 897 - 911 |
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| Autores principales: | , , , |
| Formato: | research systematic review tables/charts Journal Article |
| Publicado: |
Springer Nature
Aug2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=137419899&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 137419899 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00283940 NYZ jtl: Neuroradiology issn: 00283940 maglogo: N pubinfo: dt: Aug2019 vid: 61 iid: 8 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 137419899 137419899 137419899 10.1007/s00234-019-02236-7 137419899 ppf: 897 ppct: 14 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Differentiation of lymphomatous, metastatic, and non-malignant lymphadenopathy in the neck with quantitative diffusion-weighted imaging: systematic review and meta-analysis. aug: au: Payabvash, Seyedmehdi Brackett, Alexandria Forghani, Reza Malhotra, Ajay affil: Department of Radiology and Biomedical Imaging, Yale School of Medicine, Box 208042, 333 Cedar St, Tompkins East 2, 06520-8042, New Haven, CT, USA sug: subj: Neck Pathology Lymph Nodes Pathology Lymphatic Diseases Classification Lymphatic Diseases Diagnosis Magnetic Resonance Imaging Methods Human Systematic Review Meta Analysis Medline Embase Cochrane Library Confidence Intervals Odds Ratio ROC Curve Lymphoma Diagnosis Neoplasm Metastasis Diagnosis Predictive Value of Tests ab: Purpose: To perform a systematic review and meta-analysis of literature comparing average apparent diffusion coefficient (ADC) for differentiating lymphomatous, metastatic, and non-malignant cervical lymphadenopathy. Methods: We performed a comprehensive literature search of Ovid MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, and Web of Science Core Collection. Studies comparing average ADC of lymphomatous, metastatic, and non-malignant neck lymph nodes were included. The standardized mean difference and 95% confidence interval (CI) was calculated using random-effects models. In subgroup analysis of those studies applying ADC threshold for differentiation of cervical lymphadenopathy, pooled diagnostic odds ratio (DOR) and summary receiver operating characteristics (sROC) area under the curve (AUC) were determined. Results: A total of 27 studies with 1165 patients were included, pooling data from 225 lymphomatous, 1162 metastatic, and 1333 non-malignant cervical lymph nodes. The average ADC values were lower in lymphomatous compared to metastatic nodes, and in metastatic compared to non-malignant nodes with a standardized mean difference of − 1.36 (95% CI: − 1.71 to − 1.01, p < 0.0001) and − 1.61 (95% CI: − 2.19 to − 1.04, p < 0.0001), respectively. In subgroup analysis, applying ADC threshold could differentiate lymphomatous from metastatic lymphadenopathy with DOR of 52.07 (95% CI 25.45–106.54) and sROC AUC of 0.936 (95% CI 0.896–0.979) and differentiate metastatic from non-malignant nodes with DOR of 39.45 (95% CI 16.92–92.18) and sROC AUC of 0.929 (95% CI 0.873–0.966). Conclusions: Quantitative assessment of ADC can help with differentiation of suspicious cervical lymph nodes, particularly in those patients without prior history of malignancy or unknown primary cancer site. pubtype: Academic Journal doctype: meta analysis research systematic review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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