Association between native T1 mapping of the kidney and renal fibrosis in patients with IgA nephropathy.
Introduction: IgA nephropathy (IgAN) is the commonest global cause of glomerulonephritis. Extent of fibrosis, tubular atrophy and glomerulosclerosis predict renal function decline. Extent of renal fibrosis is assessed with renal biopsy which is invasive and prone to sampling error. We assessed the u...
| Publicado en: | BMC Nephrology Vol. 20; no. 1 |
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| Autores principales: | , , , , , , , |
| Formato: | research Journal Article |
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BioMed Central
7/11/2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=137440961&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 137440961 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14712369 1CI6 jtl: BMC Nephrology issn: 14712369 maglogo: N pubinfo: dt: 7/11/2019 vid: 20 iid: 1 pid: 24147 pub: BioMed Central artinfo: ui: 137440961 137440961 NLM31296183 137440961 10.1186/s12882-019-1447-2 NLM31296183 137440961 ppct: 1 formats: tig: atl: Association between native T1 mapping of the kidney and renal fibrosis in patients with IgA nephropathy. aug: au: Graham-Brown, M. P. Singh, A. Wormleighton, J. Brunskill, N. J. McCann, G. P. Barratt, J. Burton, J. O. Xu, G. affil: John Walls Renal Unit, University Hosptials of Leicester NHS Trust, Leicester, UK sug: subj: Glomerulonephritis Complications Kidney Magnetic Resonance Imaging Methods Kidney Pathology Pilot Studies Human Kidney Diseases Etiology Fibrosis Middle Age Adult Male Female Fibrosis Etiology Prospective Studies Severity of Illness Indices Kidney Diseases Pathology Kidney Diseases Validation Studies Comparative Studies Evaluation Research Multicenter Studies Ferrans and Powers Quality of Life Index Scales Middle Aged: 45-64 years Adult: 19-44 years Male Female ab: Introduction: IgA nephropathy (IgAN) is the commonest global cause of glomerulonephritis. Extent of fibrosis, tubular atrophy and glomerulosclerosis predict renal function decline. Extent of renal fibrosis is assessed with renal biopsy which is invasive and prone to sampling error. We assessed the utility of non-contrast native T1 mapping of the kidney in patients with IgAN for assessment of renal fibrosis.Methods: Renal native T1 mapping was undertaken in 20 patients with IgAN and 10 healthy subjects. Ten IgAN patients had a second scan to assess test-retest reproducibility of the technique. Native T1 times were compared to markers of disease severity including degree of fibrosis, eGFR, rate of eGFR decline and proteinuria.Results: All patients tolerated the MRI scan and analysable quality T1 maps were acquired in at least one kidney in all subjects. Cortical T1 times were significantly longer in patients with IgAN than healthy subjects (1540 ms ± 110 ms versus 1446 ± 88 ms, p = 0.038). There was excellent test-retest reproducibility of the technique, with Coefficient-of-variability of axial and coronal T1 mapping analysis being 2.9 and 3.7% respectively. T1 correlated with eGFR and proteinuria (r = - 0.444, p = 0.016; r = 0.533, p = 0.003 respectively). Patients with an eGFR decline > 2 ml/min/year had increased T1 times compared to those with a decline < 2 ml/min/year (1615 ± 135 ms versus 1516 ± 87 ms, p = 0.068), and T1 time was also higher in patients with a histological 'T'-score of > 0, compared to those with a 'T'-score of 0 (1575 ± 106 ms versus 1496 ± 105 ms, p = 0.131), though not to significance.Conclusions: Cortical native T1 time is significantly increased in patients with IgAN compared to healthy subjects and correlates with markers of renal disease. Reproducibility of renal T1 mapping is excellent. This study highlights the potential utility of native T1 mapping in IgAN and other progressive nephropathies, and larger prospective studies are warranted. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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