Structural brain characteristics of anabolic–androgenic steroid dependence in men.
Aim: To identify differences in brain morphology between dependent and non‐dependent male anabolic–androgenic steroid (AAS) users. Design This study used cross‐sectional data from a longitudinal study on male weightlifters. Participants: Oslo University Hospital, Norway. Setting: Eighty‐one AAS user...
| Publicado en: | Addiction Vol. 114; no. 8; pp. 1405 - 1416 |
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| Autores principales: | , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Aug2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=137451113&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 137451113 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09652140 AIO jtl: Addiction issn: 09652140 maglogo: Y pubinfo: dt: Aug2019 vid: 114 iid: 8 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 137451113 137451113 137451113 10.1111/add.14629 137451113 ppf: 1405 ppct: 11 formats: fmt: – @attributes: type: T – @attributes: type: C – @attributes: type: P tig: atl: Structural brain characteristics of anabolic–androgenic steroid dependence in men. aug: au: Hauger, Lisa E. Westlye, Lars T. Fjell, Anders M. Walhovd, Kristine B. Bjørnebekk, Astrid affil: The Anabolic Androgenic Steroid Research Group, National Advisory Unit on Substance Use Disorder Treatment, the Division of Mental Health and Addiction, Oslo University Hospital, Oslo Norway sug: subj: Men's Health Brain Anatomy and Histology Substance Dependence Anabolic Steroids Persons with Substance Use Disorders Human Secondary Analysis Weight Lifting Academic Medical Centers Norway Magnetic Resonance Imaging Neuroanatomy Cerebral Cortex Anatomy and Histology Semi-Structured Interview Structured Interview Guides Frontal Lobe Self Regulation Emotions ab: Aim: To identify differences in brain morphology between dependent and non‐dependent male anabolic–androgenic steroid (AAS) users. Design This study used cross‐sectional data from a longitudinal study on male weightlifters. Participants: Oslo University Hospital, Norway. Setting: Eighty‐one AAS users were divided into two groups; AAS‐dependent (n = 43) and AAS‐non‐dependent (n = 38). Measurements Neuroanatomical volumes and cerebral cortical thickness were estimated based on magnetic resonance imaging (MRI) using FreeSurfer. Background and health information were obtained using a semi‐structured interview. AAS‐dependence was evaluated in a standardized clinical interview using a version of the Structured Clinical Interview for DSM‐IV, adapted to apply to AAS‐dependence. Findings Compared with non‐dependent users, dependent users had significantly thinner cortex in three clusters of the right hemisphere and in five clusters of the left hemisphere, including frontal, temporal, parietal and occipital regions. Profound differences were seen in frontal regions (left pars orbitalis, cluster‐wise P < 0.001, right superior frontal, cluster‐wise P < 0.001), as has been observed in other dependencies. Group differences were also seen when excluding participants with previous or current non‐AAS drug abuse (left pre‐central, cluster‐wise P < 0.001, left pars orbitalis, cluster‐wise P = 0.010). Conclusion: Male dependent anabolic–androgenic steroid users appear to have thinner cortex in widespread regions, specifically in pre‐frontal areas involved in inhibitory control and emotional regulation, compared with non‐dependent anabolic–androgenic steroid users. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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