Resolving Clinical Trial Subject Disengagement in Socioeconomically Disadvantaged Subjects.
BACKGROUND: Clinical trialists may be reluctant to enroll socioeconomically disadvantaged participants because of concerns for subject disengagement leading to noncompliance with longitudinal measures and high lost to follow-up (LTFU) rates. OBJECTIVES: We describe the LTFU problem associated with d...
| Publicado en: | Journal of Neuroscience Nursing Vol. 51; no. 4; pp. 164 - 169 |
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| Autores principales: | , , , |
| Formato: | pictorial research Journal Article |
| Publicado: |
Lippincott Williams & Wilkins
Aug2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=137452399&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 137452399 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 08880395 38Z jtl: Journal of Neuroscience Nursing issn: 08880395 maglogo: N pubinfo: dt: Aug2019 vid: 51 iid: 4 pid: 433 pub: Lippincott Williams & Wilkins place: Baltimore, Maryland artinfo: ui: 137452399 137452399 137452399 10.1097/JNN.0000000000000449 137452399 ppf: 164 ppct: 5 formats: tig: atl: Resolving Clinical Trial Subject Disengagement in Socioeconomically Disadvantaged Subjects. aug: au: Rhudy, James P. Lewis, Jonathan C. Alexandrov, Andrei V. Alexandrov, Anne W. affil: Jonathan C. Lewis, MDiv BCC, is Program Manager of UT and Conference Ministries, Faith and Health Division, Methodist Le Bonheur Healthcare, Memphis, TN. sug: subj: Clinical Trials Research Subjects Disengagement Prevention and Control Socioeconomic Factors Strategic Planning Human Research Subject Recruitment Research Subject Retention Geographic Information Systems Health Status Disparities Clinical Exemplars ab: BACKGROUND: Clinical trialists may be reluctant to enroll socioeconomically disadvantaged participants because of concerns for subject disengagement leading to noncompliance with longitudinal measures and high lost to follow-up (LTFU) rates. OBJECTIVES: We describe the LTFU problem associated with disadvantaged participants and propose strategies to reduce clinical trial disengagement. METHODS: Difficulties encountered in recruiting and retaining socioeconomically disadvantaged participants along with antecedents of disengagement are discussed. Data in the public domain were used to derive, symbolize, and map engagement by census tract. Exemplars of engaged and disengaged clinical trial participants are shared, and geospatial distribution of socio-spatial disengagement risk is presented. RESULTS: Subject disengagement can be visualized by geospatial informatics suggesting areas of low and high socio-spatial disengagement risk. By failing to enroll socioeconomically disadvantaged subjects, researchers may deliberately exclude those who may benefit the most because of significant health disparities. DISCUSSION: We propose a study of realistic LTFU rates for disadvantaged participants. Realistic clinical trial end points and methods may reduce disengagement among disadvantaged participants. pubtype: Academic Journal doctype: pictorial research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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