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Updates on Management of Adult Medulloblastoma.

Opinion Statement: Medulloblastoma (MB) is a malignant embryonal tumor of the posterior fossa and is the most common type of brain cancer in pediatric patients. In contrast, adult MB is very rare with an incidence of 0.6 per million per year and mostly affects young adults below the age of 40. Recen...

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Published in:Current Treatment Options in Oncology Vol. 20; no. 8
Main Authors: Majd, Nazanin, Penas-Prado, Marta
Format: research Journal Article
Published: Springer Nature Aug2019
Online Access:View this record in EBSCOhost
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      dt: Aug2019
      vid: 20
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      pub: Springer Nature
      place: New York, New York
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        10.1007/s11864-019-0663-0
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        atl: Updates on Management of Adult Medulloblastoma.
      aug:
        au:
          Majd, Nazanin
          Penas-Prado, Marta
        affil: MD Anderson Cancer Center Department of Neuro-oncology, 1515 Holcombe Blvd., 77030, Houston, TX, USA
      sug:
        subj:
          Brain Neoplasms Diagnosis
          Glioma Diagnosis
          Glioma Therapy
          Brain Neoplasms Therapy
          Combined Modality Therapy
          Diagnostic Imaging
          Glioma Etiology
          Neoplasm Metastasis
          Glioma Mortality
          Human
          Brain Neoplasms Etiology
          Brain Neoplasms Mortality
          Disease Management
          Clinical Trials
          Neoplasm Staging
          Treatment Outcomes
          Neoplasm Grading
          Scales
      ab: Opinion Statement: Medulloblastoma (MB) is a malignant embryonal tumor of the posterior fossa and is the most common type of brain cancer in pediatric patients. In contrast, adult MB is very rare with an incidence of 0.6 per million per year and mostly affects young adults below the age of 40. Recent molecular analyses of pediatric and adult MB have classified these tumors into at least four individual molecular subgroups (SHH, WNT, group 3, and group 4) with distinct demographics, histology, and prognosis. The discrete biological composition of these tumors likely explains the marked heterogeneity in responses seen to conventional therapies such as radiation and cytotoxic chemotherapies. Given the low incidence of adult MB, prospective studies are challenging and scarce, and management guidelines are largely derived from the pediatric MB patient population and retrospective data. However, adult MB is clinically and molecularly distinct from pediatric MB and a comprehensive review of published literature on adult MB highlighting their differences is warranted. Here, we review the management of adult MB focusing on recent studies exploring the effectiveness of upfront chemotherapy, clinical trials in the context of molecular subgroup-specific therapies, and the potential role of immunotherapy in treating this disease.
      pubtype: Academic Journal
      doctype:
        research
        Journal Article
      ougenre: Article
    language: English
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