Persistent increase of I.V. cocaine self-administration in a subgroup of C57BL/6J male mice after social defeat stress.
Rationale: Stressful life experiences can persistently increase the motivation for, and consumption of, intensely rewarding stimuli, like cocaine, over time. In rodents, intermittent versus continuous exposure to social stress engenders opposing changes to reward-related behavior, as measured by con...
| Publicado en: | Psychopharmacology Vol. 236; no. 7; pp. 2027 - 2038 |
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| Autores principales: | , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Jul2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=137472316&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 137472316 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00333158 EJD jtl: Psychopharmacology issn: 00333158 maglogo: N pubinfo: dt: Jul2019 vid: 236 iid: 7 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 137472316 10.1007/s00213-019-05191-6 137472316 ppf: 2027 ppct: 11 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Persistent increase of I.V. cocaine self-administration in a subgroup of C57BL/6J male mice after social defeat stress. aug: au: Arena, Danielle T. Covington III, Herbert E. DeBold, Joseph F. Miczek, Klaus A. affil: Department of Psychology, Tufts University, 02144, Medford, MA, USA sug: ab: Rationale: Stressful life experiences can persistently increase the motivation for, and consumption of, intensely rewarding stimuli, like cocaine, over time. In rodents, intermittent versus continuous exposure to social stress engenders opposing changes to reward-related behavior, as measured by consumption of sucrose and cocaine. Objective: The present study examines if the effects of intermittent versus continuous social stress on cocaine self-administration in mice parallel those seen in rats. Methods: Both forms of social stress involve a brief daily physical confrontation with an aggressive resident for 10 consecutive days. Continuous social stress involves constant visual and olfactory exposure to an aggressive resident via habitation in a protected portion of the resident's home cage, while exposure to an aggressive resident during intermittent social stress is limited to a single, physical encounter per day. Implementing a femoral vein catheterization method for the first time in mice, we determined divergent changes to intravenous cocaine self-administration. Results: Modestly increased cocaine self-administration after intermittent social stress was confirmed. In a subset of animals, continuous social stress in mice substantially increased cocaine self-administration and sucrose intake. By stark contrast, another subpopulation had substantial attenuation of cocaine self-administration and sucrose intake after continuous social stress. Conclusions: Bimodal divergence in responding for rewarding stimuli including cocaine after social stress experience likely reflects two opposing forms of coping to continuous social stress that promote either a sensitization or attenuation of reward-seeking. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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