NBN Gene Analysis and it's Impact on Breast Cancer.
Single Nucleotide Polymorphism (SNP) researches have become essential in finding out the congenital relationship of structural deviations with quantitative traits, heritable diseases and physical responsiveness to different medicines. NBN is a protein coding gene (Breast Cancer); Nibrin is used to f...
| Publicado en: | Journal of Medical Systems Vol. 43; no. 8 |
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| Autores principales: | , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Aug2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=137490019&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 137490019 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01485598 4N0 jtl: Journal of Medical Systems issn: 01485598 maglogo: N pubinfo: dt: Aug2019 vid: 43 iid: 8 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 137490019 137490019 137490019 10.1007/s10916-019-1328-z 137490019 ppct: 1 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: NBN Gene Analysis and it's Impact on Breast Cancer. aug: au: Nithya, P. ChandraSekar, A. affil: CSE Department, St. Joseph's College of Engineering, Chennai, Tamil Nadu, India sug: subj: Proteins Polymorphism, Genetic Breast Neoplasms Data Analysis Software Anemia, Aplastic Nijmegen Breakage Syndrome Hereditary Diseases Amino Acids Data Mining Mutation Models, Structural ab: Single Nucleotide Polymorphism (SNP) researches have become essential in finding out the congenital relationship of structural deviations with quantitative traits, heritable diseases and physical responsiveness to different medicines. NBN is a protein coding gene (Breast Cancer); Nibrin is used to fix and rebuild the body from damages caused because of strand breaks (both singular and double) associated with protein nibrin. NBN gene was retrieved from dbSNP/NCBI database and investigated using computational SNP analysis tools. The encrypted region in SNPs (exonal SNPs) were analyzed using software tools, SIFT, Provean, Polyphen, INPS, SNAP and Phd-SNP. The 3'ends of SNPs in un-translated region were also investigated to determine the impact of binding. The association of NBN gene polymorphism leads to several diseases was studied. Four SNPs were predicted to be highly damaged in coding regions which are responsible for the diseases such as, Aplastic Anemia, Nijmegan breakage syndrome, Microsephaly normal intelligence, immune deficiency and hereditary cancer predisposing syndrome (clivar). The present study will be helpful in finding the suitable drugs in future for various diseases especially for breast cancer. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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