Effect of itraconazole, food, and ethnic origin on the pharmacokinetics of ivosidenib in healthy subjects.

Purpose: To assess the effect of ethnicity, food, and itraconazole (strong CYP3A4 inhibitor) on the pharmacokinetics of ivosidenib after single oral doses in healthy subjects. Methods: Three phase 1 open-label studies were performed. Study 1: Japanese and Caucasian subjects received single doses of...

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Bibliographic Details

Published in:	European Journal of Clinical Pharmacology Vol. 75; no. 8; pp. 1099 - 1109
Main Authors:	Dai, David, Yang, Hua, Nabhan, Salah, Liu, Hua, Hickman, Denice, Liu, Guowen, Zacher, Jeffrey, Vutikullird, Apinya, Prakash, Chandra, Agresta, Samuel, Bowden, Chris, Fan, Bin
Format:	research tables/charts randomized controlled trial Journal Article
Published:	Springer Nature Aug2019
Online Access:	View this record in EBSCOhost