Fractal dimension brain morphometry: a novel approach to quantify white matter in traumatic brain injury.
Traumatic brain injury (TBI) is the main cause of disability in people younger than 35 in the United States. The mechanisms of TBI are complex resulting in both focal and diffuse brain damage. Fractal dimension (FD) is a measure that can characterize morphometric complexity and variability of brain...
| Publicado en: | Brain Imaging & Behavior Vol. 13; no. 4; pp. 914 - 925 |
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| Autores principales: | , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Aug2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=137507310&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 137507310 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19317557 3GSC jtl: Brain Imaging & Behavior issn: 19317557 maglogo: N pubinfo: dt: Aug2019 vid: 13 iid: 4 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 137507310 137507310 NLM29909586 10.1007/s11682-018-9892-2 NLM29909586 137507310 ppf: 914 ppct: 11 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Fractal dimension brain morphometry: a novel approach to quantify white matter in traumatic brain injury. aug: au: Rajagopalan, Venkateswaran Das, Abhijit Zhang, Luduan Hillary, Frank Wylie, Glenn R. Yue, Guang H. affil: Department of Electrical and Electronics Engineering, Birla Institute of Technology and Science, Pilani, Hyderabad Campus, Hyderabad, India sug: subj: Magnetic Resonance Imaging Methods Brain Adult Brain Anatomy and Histology Brain Injuries Complications Female Neuropsychological Tests Male Cognition Disorders Etiology Image Processing, Computer Assisted Adolescence Image Interpretation, Computer Assisted Methods Adult: 19-44 years Adolescent: 13-18 years Female Male ab: Traumatic brain injury (TBI) is the main cause of disability in people younger than 35 in the United States. The mechanisms of TBI are complex resulting in both focal and diffuse brain damage. Fractal dimension (FD) is a measure that can characterize morphometric complexity and variability of brain structure especially white matter (WM) structure and may provide novel insights into the injuries evident following TBI. FD-based brain morphometry may provide information on WM structural changes after TBI that is more sensitive to subtle structural changes post injury compared to conventional MRI measurements. Anatomical and diffusion tensor imaging (DTI) data were obtained using a 3 T MRI scanner in subjects with moderate to severe TBI and in healthy controls (HC). Whole brain WM volume, grey matter volume, cortical thickness, cortical area, FD and DTI metrics were evaluated globally and for the left and right hemispheres separately. A neuropsychological test battery sensitive to cognitive impairment associated with traumatic brain injury was performed. TBI group showed lower structural complexity (FD) bilaterally (p < 0.05). No significant difference in either grey matter volume, cortical thickness or cortical area was observed in any of the brain regions between TBI and healthy controls. No significant differences in whole brain WM volume or DTI metrics between TBI and HC groups were observed. Behavioral data analysis revealed that WM FD accounted for a significant amount of variance in executive functioning and processing speed beyond demographic and DTI variables. FD therefore, may serve as a sensitive marker of injury and may play a role in outcome prediction in TBI. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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