12-h abstinence-induced functional connectivity density changes and craving in young smokers: a resting-state study.
Studying the neural correlates of craving to smoke is of great importance to improve treatment outcomes in smoking addiction. According to previous studies, the critical roles of striatum and frontal brain regions had been revealed in addiction. However, few studies focused on the hub of brain regio...
| Publicado en: | Brain Imaging & Behavior Vol. 13; no. 4; pp. 953 - 963 |
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| Autores principales: | , , , , , , , , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
Springer Nature
Aug2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=137507316&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 137507316 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19317557 3GSC jtl: Brain Imaging & Behavior issn: 19317557 maglogo: N pubinfo: dt: Aug2019 vid: 13 iid: 4 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 137507316 137507316 NLM29926324 137507316 10.1007/s11682-018-9911-3 NLM29926324 137507316 ppf: 953 ppct: 10 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: 12-h abstinence-induced functional connectivity density changes and craving in young smokers: a resting-state study. aug: au: Zhao, Shuzhi Li, Yangding Li, Min Wang, Ruonan Bi, Yanzhi Zhang, Yajuan Lu, Xiaoqi Yu, Dahua Yang, Likun Yuan, Kai affil: College of Computer Science and Information Technology, Guangxi Normal University, 541004, Guilin, Guangxi, People's Republic of China sug: subj: Behavior, Addictive Physiopathology Craving Smoking Physiopathology Substance Abstinence Relaxation Craving Drug Effects Behavior, Addictive Young Adult Cerebral Cortex Physiopathology Brain Mapping Substance Use Disorders Physiopathology Frontal Lobe Physiopathology Brain Mapping Methods Male Neural Pathways Physiopathology Magnetic Resonance Imaging Basal Ganglia Limbic System Physiopathology Brain Physiopathology Adolescence Human Adolescent: 13-18 years Male ab: Studying the neural correlates of craving to smoke is of great importance to improve treatment outcomes in smoking addiction. According to previous studies, the critical roles of striatum and frontal brain regions had been revealed in addiction. However, few studies focused on the hub of brain regions in the 12 h abstinence induced craving in young smokers. Thirty-one young male smokers were enrolled in the present study. A within-subject experiment design was carried out to compare functional connectivity density between 12-h smoking abstinence and smoking satiety conditions during resting state in young adult smokers by using functional connectivity density mapping (FCDM). Then, the functional connectivity density changes during smoking abstinence versus satiety were further used to examine correlations with abstinence-induced changes in subjective craving. We found young adult smokers in abstinence state (vs satiety) had higher local functional connectivity density (lFCD) and global functional connectivity density (gFCD) in brain regions including striatal subregions (i.e., bilateral caudate and putamen), frontal regions (i.e., anterior cingulate cortex (ACC) and orbital frontal cortex (OFC)) and bilateral insula. We also found higher lFCD during smoking abstinence (vs satiety) in bilateral thalamus. Additionally, the lFCD changes of the left ACC, bilateral caudate and right OFC were positively correlated with the changes in craving induced by abstinence (i.e., abstinence minus satiety) in young adult smokers. The present findings improve the understanding of the effects of acute smoking abstinence on the hubs of brain gray matter in the abstinence-induces craving and may contribute new insights into the neural mechanism of abstinence-induced craving in young smokers in smoking addiction. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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