Language function shows comparable cortical patterns by functional MRI and repetitive nTMS in healthy volunteers.
In preoperative planning, fMRI and repetitive navigated transcranial magnetic stimulation (rTMS) repeatedly revealed differences in the detected language sites, which can be attributed to tumor-induced oxygenation changes impairing the accuracy of fMRI. We therefore compared the accordance of those...
| Publicado en: | Brain Imaging & Behavior Vol. 13; no. 4; pp. 1071 - 1093 |
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| Autores principales: | , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Aug2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=137507325&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 137507325 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19317557 3GSC jtl: Brain Imaging & Behavior issn: 19317557 maglogo: N pubinfo: dt: Aug2019 vid: 13 iid: 4 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 137507325 137507325 NLM29981018 10.1007/s11682-018-9921-1 NLM29981018 137507325 ppf: 1071 ppct: 22 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Language function shows comparable cortical patterns by functional MRI and repetitive nTMS in healthy volunteers. aug: au: Hauck, Theresa Probst, Monika Zimmer, Claus Ringel, Florian Meyer, Bernhard Wohlschlaeger, Afra Krieg, Sandro M. affil: Department of Neurosurgery, Klinikum rechts der Isar, Technische Universität München, Ismaninger Str. 22, 81675, Munich, Germany sug: subj: Transcranial Magnetic Stimulation Methods Brain Mapping Methods Verbal Behavior Adult Dominance, Cerebral Parietal Lobe Male Research Subjects Speech Physiology Cerebral Cortex Physiology Language Magnetic Resonance Imaging Methods Brain Reading Female Clinical Assessment Tools Adult: 19-44 years Male Female ab: In preoperative planning, fMRI and repetitive navigated transcranial magnetic stimulation (rTMS) repeatedly revealed differences in the detected language sites, which can be attributed to tumor-induced oxygenation changes impairing the accuracy of fMRI. We therefore compared the accordance of those techniques in healthy subjects using exactly the same tasks in both investigations. 19 healthy right-handed subjects performed object naming, pseudoword reading, verb generation, and action naming during fMRI at 3 T and rTMS. For rTMS language mapping, we stimulated 46 cortical spots over the left hemisphere; each site was stimulated for three times. Language positive points during rTMS for one, two, or three errors out the three stimulations per spot (1/3, 2/3, 3/3) were exported via DICOM, and compared to the positive fMRI clusters. As a result of this comparison, the best correlation was observed between 3/3 errors and fMRI for pseudoword reading and verb generation with t-values of pu < 0.001, uncorrected for multiple comparisons, on average across the whole rTMS-spot map. We found a close spatial agreement between several rTMS-spots (2/3 and 3/3 errors) and fMRI clusters accentuated in the frontal lobe, followed by the parietal lobe and less in the temporal lobe. Compared to the fMRI clusters, there was a higher congruence for 2/3 and 3/3 errors than for 1/3 errors. Overall, results of language mapping in healthy subjects by fMRI and rTMS correspond well yet depending on the used language task. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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