Radiation-induced hippocampal atrophy in patients with nasopharyngeal carcinoma early after radiotherapy: a longitudinal MR-based hippocampal subfield analysis.
Increasing evidence indicates that radiation-induced injury to the hippocampus may play a critical role in neurocognitive dysfunction in patients with nasopharyngeal carcinoma (NPC). However, few studies have assessed RT-induced hippocampal structural alterations in these patients early after radiot...
| Publicado en: | Brain Imaging & Behavior Vol. 13; no. 4; pp. 1160 - 1172 |
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| Autores principales: | , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Aug2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=137507335&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 137507335 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19317557 3GSC jtl: Brain Imaging & Behavior issn: 19317557 maglogo: N pubinfo: dt: Aug2019 vid: 13 iid: 4 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 137507335 137507335 NLM30054872 10.1007/s11682-018-9931-z NLM30054872 137507335 ppf: 1160 ppct: 12 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Radiation-induced hippocampal atrophy in patients with nasopharyngeal carcinoma early after radiotherapy: a longitudinal MR-based hippocampal subfield analysis. aug: au: Lv, Xiaofei He, Haoqiang Yang, Yadi Han, Lujun Guo, Zheng Chen, Hong Li, Jing Qiu, Yingwei Xie, Chuanmiao affil: Department of Medical Imaging, Sun Yat-sen University Cancer Center sug: subj: Cognition Hippocampus Radiation Effects Radiotherapy Adverse Effects Middle Age Prospective Studies Temporal Lobe Pathology Adult Male Female Hippocampus Pathology Magnetic Resonance Imaging Methods Atrophy Pathology Nasopharyngeal Neoplasms Radiation Brain Pathology Scales Middle Aged: 45-64 years Adult: 19-44 years Male Female ab: Increasing evidence indicates that radiation-induced injury to the hippocampus may play a critical role in neurocognitive dysfunction in patients with nasopharyngeal carcinoma (NPC). However, few studies have assessed RT-induced hippocampal structural alterations in these patients early after radiotherapy (RT). In this study, 58 NPC patients were longitudinally followed up prior to treatment initiation as well as 3 and 6 months after RT, respectively. Twenty comparable normal controls were recruited and followed up in parallel. A novel magnetic resonance imaging (MRI)-based automated method was used to label hippocampal subfields. The linear mixed model was employed to evaluate longitudinal changes in the volumes of the whole hippocampus and seven hippocampal subfields. Time-dependent volume reduction was observed in the bilateral hippocampus, as well as in the bilateral granule cell layer (GCL), bilateral cornu ammonis 1 (CA1), bilateral molecular layer (ML), and bilateral subiculum (SUB) in NPC patients, but not in controls. Moreover, volume deficits in the bilateral hippocampus, bilateral GCL, and right ML showed dose-dependent patterns, and high volume losses in the bilateral hippocampus, bilateral GCL, left SUB, and right ML were associated with a rapid decline in cognitive function. Our findings demonstrated that the hippocampal subfields were selectively injured by irradiation-related early neurotoxic effects, which might account for cognitive impairment in NPC patients at an early stage after RT. Further, structural MRI could serve as a potential noninvasive imaging biomarker for the early detection of radiation effects on the hippocampus in NPC patients after RT. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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