Effects of vitamin D supplementation on metabolic and endocrine parameters in PCOS: a randomized-controlled trial.
Purpose: Vitamin D status may be associated with insulin resistance and other key features of polycystic ovary syndrome (PCOS), but data from preliminary randomized controlled trials (RCTs) are conflicting. Therefore, we aimed to investigate the effects of vitamin D supplementation on plasma glucose...
| Publicado en: | European Journal of Nutrition Vol. 58; no. 5; pp. 2019 - 2029 |
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| Autores principales: | , , , , , , , , , |
| Formato: | equations & formulas research tables/charts randomized controlled trial Journal Article |
| Publicado: |
Springer Nature
Aug2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=137590661&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 137590661 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14366207 CR0 jtl: European Journal of Nutrition issn: 14366207 maglogo: N pubinfo: dt: Aug2019 vid: 58 iid: 5 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 137590661 137590661 137590661 10.1007/s00394-018-1760-8 137590661 ppf: 2019 ppct: 10 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Effects of vitamin D supplementation on metabolic and endocrine parameters in PCOS: a randomized-controlled trial. aug: au: Trummer, Christian Schwetz, Verena Kollmann, Martina Wölfler, Monika Münzker, Julia Pieber, Thomas R. Pilz, Stefan Heijboer, Annemieke C. Obermayer-Pietsch, Barbara Lerchbaum, Elisabeth affil: Division of Endocrinology and Diabetology, Department of Internal Medicine, Medical University of Graz, Auenbruggerplatz 15, 8036, Graz, Austria sug: subj: Vitamin D Pharmacodynamics Energy Metabolism Drug Effects Endocrine System Drug Effects Blood Glucose Drug Effects Blood Glucose Metabolism Dietary Supplementation Polyendocrine Metabolic Ovarian Syndrome Drug Therapy Human Randomized Controlled Trials Treatment Outcomes Double-Blind Studies Female Academic Medical Centers Cholecalciferol Administration and Dosage Adult Young Adult Fasting Confidence Intervals Glucose Tolerance Test Vitamin D Deficiency Drug Therapy Insulin Resistance Drug Therapy Vitamin D Deficiency Risk Factors Insulin Resistance Risk Factors Adult: 19-44 years Female ab: Purpose: Vitamin D status may be associated with insulin resistance and other key features of polycystic ovary syndrome (PCOS), but data from preliminary randomized controlled trials (RCTs) are conflicting. Therefore, we aimed to investigate the effects of vitamin D supplementation on plasma glucose area under the curve (AUCgluc, primary outcome measure) and on other metabolic and endocrine parameters (secondary outcome measures). Methods: This study was a single-center, double-blind, randomized placebo-controlled trial conducted between December 2011 and July 2017 at the Medical University of Graz, Austria. One-hundred and eighty women with PCOS and 25-hydroxyvitamin D [25(OH)D] concentrations < 75 nmol/L were randomized in a 2:1 ratio to either receive 20,000 IU of cholecalciferol weekly or placebo over 24 weeks. Primary outcome was the between-group difference in AUCgluc at study end while adjusting for baseline values. Results: In total, 123 participants completed the study [age 25.9 ± 4.7 years; BMI 27.5 ± 7.3 kg/m2; baseline 25(OH)D 48.8 ± 16.9 nmol/L, baseline fasting glucose 84 ± 8 mg/dL]. Vitamin D supplementation lead to a significant increase in 25(OH)D [mean treatment effect 33.4 nmol/L; 95% confidence interval (CI) 24.5 to 42.2; p < 0.001] but had no significant effect on AUCgluc (mean treatment effect − 9.19; 95% CI − 21.40 to 3.02; p = 0.139). Regarding secondary outcome measures, we observed a significant decrease in plasma glucose at 60 min during oral glucose tolerance test (mean treatment effect − 10.2 mg/dL; 95% CI − 20.2 to − 0.3; p = 0.045). Conclusions: Vitamin D supplementation had no significant effect on metabolic and endocrine parameters in PCOS with the exception of a reduced plasma glucose during OGTT. pubtype: Academic Journal doctype: equations & formulas research tables/charts randomized controlled trial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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