Effects of downslope walking on Soleus H-reflexes and walking function in individuals with multiple sclerosis: A preliminary study.

BACKGROUND: Downslope walking (DSW) is an eccentric-based exercise intervention that promotes neuroplasticity of spinal reflex circuitry by inducing depression of Soleus Hoffman (H)-reflexes in young, neurologically unimpaired adults. OBJECTIVE: The objective of the study was to evaluate the effects...

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Published in:NeuroRehabilitation Vol. 44; no. 4; pp. 587 - 598
Main Authors: Hoque, Maruf, Borich, Michael, Sabatier, Manning, Backus, Deborah, Kesar, Trisha
Format: research tables/charts Journal Article
Published: Sage Publications Inc. 2019
Online Access:View this record in EBSCOhost
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      dt: 2019
      vid: 44
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      pub: Sage Publications Inc.
      place: Thousand Oaks, California
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        10.3233/NRE-192701
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        atl: Effects of downslope walking on Soleus H-reflexes and walking function in individuals with multiple sclerosis: A preliminary study.
      aug:
        au:
          Hoque, Maruf
          Borich, Michael
          Sabatier, Manning
          Backus, Deborah
          Kesar, Trisha
        affil: Department of Rehabilitation Medicine, Division of Physical Therapy, Emory University School of Medicine, Atlanta, GA, USA
      sug:
        subj:
          Multiple Sclerosis Psychosocial Factors
          Walking Physiology
          H-Reflex Physiology
          Spinal Cord Physiology
          Human
          Male
          Female
          Adult
          Middle Age
          Treadmills Utilization
          Exercise Physiology
          Comparative Studies
          Adult: 19-44 years
          Middle Aged: 45-64 years
          Male
          Female
      ab: BACKGROUND: Downslope walking (DSW) is an eccentric-based exercise intervention that promotes neuroplasticity of spinal reflex circuitry by inducing depression of Soleus Hoffman (H)-reflexes in young, neurologically unimpaired adults. OBJECTIVE: The objective of the study was to evaluate the effects of DSW on spinal excitability (SE) and walking function (WF) in people with multiple sclerosis (PwMS). METHODS: Our study comprised two experiments on 12 PwMS (11 women; 45.3±11.8 years). Experiment 1 evaluated acute effects of a single 20-minute session of treadmill walking at three different walking grades on SE, 0% or level walking (LW), – 7.5% DSW, and – 15% DSW. Experiment 2 evaluated the effects of 6 sessions of DSW, at – 7.5% DSW (with second session being – 15% DSW) on SE and WF. RESULTS: Experiment 1 showed significantly greater acute % H-reflex depression following – 15% DSW compared to LW (p = 0.02) and – 7.5% DSW (p = 0.05). Experiment 2 demonstrated significant improvements in WF. PwMS who showed greater acute H-reflex depression during the – 15% DSW session also demonstrated greater physical activity, long-distance WF, and the ability to have greater H-reflex depression after DSW training. Significant changes were not observed in regards to SE. CONCLUSIONS: Though significant changes were not observed in SE after DSW training, we observed an improvement in WF which merits further investigation of DSW in PwMS.
      pubtype: Academic Journal
      doctype:
        research
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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