A Comprehensive Review of Local Pharmacologic Therapy for Pyoderma Gangrenosum.
Pyoderma gangrenosum (PG) is a rare, ulcerative inflammatory skin disease that most commonly occurs in patients with inflammatory bowel disease, rheumatologic diseases, or hematologic diseases. Successful treatment of PG often requires immunosuppression and appropriate wound care. Systemic corticost...
| Publicado en: | Wounds: A Compendium of Clinical Research & Practice Vol. 31; no. 6; pp. 151 - 158 |
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| Autores principales: | , , , , |
| Formato: | review tables/charts Journal Article |
| Publicado: |
HMP Global
Jun2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=137652216&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 137652216 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10447946 YZM jtl: Wounds: A Compendium of Clinical Research & Practice issn: 10447946 maglogo: N pubinfo: dt: Jun2019 vid: 31 iid: 6 pid: 20465 pub: HMP Global place: Malvern, Pennsylvania artinfo: ui: 137652216 137652216 137652216 137652216 ppf: 151 ppct: 7 formats: tig: atl: A Comprehensive Review of Local Pharmacologic Therapy for Pyoderma Gangrenosum. aug: au: Baltazar, David Haag, Carter Gupta, Angela S. Marzano, Angelo V. Ortega Loayza, Alex G. affil: College of Osteopathic Medicine of the Pacific-Northwest, Western University of Health Sciences, Pomona, CA sug: subj: Pyoderma Gangrenosum Therapy Skin Diseases Ulcer Inflammatory Bowel Diseases Complications Immunosuppression Disease Management Wound Care Adrenal Cortex Hormones Adverse Effects Cyclosporine Adverse Effects Hyperglycemia Risk Factors Osteoporosis Risk Factors Hypertension Risk Factors Weight Gain Risk Factors Pharmacological and Biological Treatments ab: Pyoderma gangrenosum (PG) is a rare, ulcerative inflammatory skin disease that most commonly occurs in patients with inflammatory bowel disease, rheumatologic diseases, or hematologic diseases. Successful treatment of PG often requires immunosuppression and appropriate wound care. Systemic corticosteroids and cyclosporine are the first-line treatments for PG. However, chronic use of these systemic agents places patients at risk for developing significant side effects, including hyperglycemia, osteoporosis, hypertension, and weight gain. Furthermore, when treating small or superficial PG ulcers, the use of local agents as monotherapies or adjuvant treatments can be ideal to control inflammation and promote healing without placing the patient at risk for many severe side effects that can be seen with long-term use of systemic agents. This literature review assesses all available local therapies in order to summarize the use and reported efficaciousness of the broad range of local treatments available for PG. pubtype: Periodical doctype: review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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