Prophylactic use of antiemetics for prevention of opioid-induced nausea and vomiting: a survey about Italian physicians' practice.
Purpose: Antiemetics are being used both for the treatment and prophylaxis of opioid-induced nausea and vomiting (OINV) in clinical practice, despite the lack of evidence for the prophylactic benefit. Studies among Japanese physicians demonstrated over 80% prescribe antiemetics, with neuroleptic ant...
| Publicado en: | Supportive Care in Cancer Vol. 27; no. 9; pp. 3531 - 3536 |
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| Autores principales: | , , , , , , , , |
| Formato: | questionnaire/scale research tables/charts Journal Article |
| Publicado: |
Springer Nature
Sep2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=137721590&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 137721590 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09414355 O1J jtl: Supportive Care in Cancer issn: 09414355 maglogo: N pubinfo: dt: Sep2019 vid: 27 iid: 9 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 137721590 137721590 NLM30684048 137721590 10.1007/s00520-019-4663-1 NLM30684048 137721590 ppf: 3531 ppct: 5 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Prophylactic use of antiemetics for prevention of opioid-induced nausea and vomiting: a survey about Italian physicians' practice. aug: au: Giusti, Raffaele Mazzotta, Marco Filetti, Marco Daniele, Gennaro Tsukuura, Hiroaki Ficorella, Corrado Porzio, Giampiero Marchetti, Paolo Verna, Lucilla affil: Medical Oncology Unit, Azienda Ospedaliero Universitaria Sant'Andrea, Via di Grottarossa 1035-39, 00189, Rome, Italy sug: subj: Analgesics, Opioid Adverse Effects Vomiting Prevention and Control Adrenal Cortex Hormones Therapeutic Use Serotonin Antagonists Therapeutic Use Antiemetics Therapeutic Use Antipsychotic Agents Therapeutic Use Nausea Prevention and Control Vomiting Chemically Induced Nausea Drug Therapy Dopamine Antagonists Therapeutic Use Physicians Prospective Studies Adult Analgesics, Opioid Therapeutic Use Nausea Chemically Induced Metoclopramide Therapeutic Use Vomiting Drug Therapy Language Cross Sectional Studies Female Male Italy Human Adult: 19-44 years Female Male ab: Purpose: Antiemetics are being used both for the treatment and prophylaxis of opioid-induced nausea and vomiting (OINV) in clinical practice, despite the lack of evidence for the prophylactic benefit. Studies among Japanese physicians demonstrated over 80% prescribe antiemetics, with neuroleptic antipsychotics as the most commonly prescribed drugs. Our objective was to elucidate the current scenario of the prophylactic use of antiemetics for OINV among Italian physicians.Methods: We conducted a web-based cross-sectional national survey. All the invited participants received an e-mail with an 11-item electronic questionnaire accessible through a direct link. Anonymity was guaranteed. According to the exploratory intent of the survey, we did not predefine any formal statistical hypothesis. Associations between variables were tested by the Pearson chi-square or the Fisher exact test.Results: From January to March 2017, 112 completed the electronic questionnaire (112/256, overall response rate, 43.7%). Nearly half of the participants were oncologists (54; 48.2%). Sixty-one (54.4%) physicians worked in palliative care units. About 45% of the interviewed prescribed prophylactic antiemetics at the beginning of opioid prescription. The most commonly chosen drugs for this purpose were prokinetics such as metoclopramide and domperidone (84%), followed by 5-HT3 antagonists (8%), neuroleptic antipsychotics (6%), and corticosteroids (2%). Ninety-one physicians (81%) declared to prescribe antiemetics at the occurrence of OINV, mainly prokinetics (N = 70; 77%).Conclusion: Italian physicians do not commonly prescribe prophylactic antiemetics for OINV. Unlike previously reported data, dopamine antagonists resulted the most commonly prescribed drugs. Prospective clinical trials are necessary to evaluate the real efficacy of this practice. pubtype: Academic Journal doctype: questionnaire/scale research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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