Evaluation of pharmacokinetic modeling strategies for in-vivo quantification of tau with the radiotracer [18F]MK6240 in human subjects.

Purpose: [18F]MK6240 was developed for PET imaging of tau aggregates, which are implicated in Alzheimer's disease. The goal of this work was to evaluate the kinetics of [18F]MK6240 and to investigate different strategies for in-vivo quantification of tau aggregates in humans. Methods: Thirty-five su...

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Publicado en:	European Journal of Nuclear Medicine & Molecular Imaging Vol. 46; no. 10; pp. 2099 - 2112
Autores principales:	Guehl, Nicolas J., Wooten, Dustin W., Yokell, Daniel L., Moon, Sung-Hyun, Dhaynaut, Maeva, Katz, Samantha, Moody, Kirsten A., Gharagouzloo, Codi, Kas, Aurélie, Johnson, Keith A., El Fakhri, Georges, Normandin, Marc D.
Formato:	Journal Article
Publicado:	Springer Nature Sep2019
Acceso en línea:	Ver este registro en EBSCOhost