Radiomics in multiple sclerosis and neuromyelitis optica spectrum disorder.
Objective: To develop and validate an individual radiomics nomogram for differential diagnosis between multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD).Methods: We retrospectively collected 67 MS and 68 NMOSD with spinal cord lesions as a primary cohort and prospectively re...
| Publicado en: | European Radiology Vol. 29; no. 9; pp. 4670 - 4678 |
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| Autores principales: | , , , , , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Sep2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=137908408&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 137908408 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Sep2019 vid: 29 iid: 9 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 137908408 137908408 NLM30770971 10.1007/s00330-019-06026-w NLM30770971 137908408 ppf: 4670 ppct: 8 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Radiomics in multiple sclerosis and neuromyelitis optica spectrum disorder. aug: au: Liu, Yaou Dong, Di Zhang, Liwen Zang, Yali Duan, Yunyun Qiu, Xiaolu Huang, Jing Dong, Huiqing Barkhof, Frederik Hu, Chaoen Fang, Mengjie Tian, Jie Li, Kuncheng affil: Department of Radiology, Beijing Tiantan Hospital, Capital Medical University, 100050, Beijing, People's Republic of China sug: subj: Neuromyelitis Optica Diagnosis Magnetic Resonance Imaging Methods Spinal Cord Spinal Cord Pathology Multiple Sclerosis Diagnosis Retrospective Design Pharmacokinetics Reproducibility of Results Prospective Studies Adult Diagnosis, Differential Neuromyelitis Optica Pathology Multiple Sclerosis Pathology Female Male Scales Adult: 19-44 years Female Male ab: Objective: To develop and validate an individual radiomics nomogram for differential diagnosis between multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD).Methods: We retrospectively collected 67 MS and 68 NMOSD with spinal cord lesions as a primary cohort and prospectively recruited 28 MS and 26 NMOSD patients as a validation cohort. Radiomic features were extracted from the spinal cord lesions. A prediction model for differentiating MS and NMOSD was built by combining the radiomic features with several clinical and routine MRI measurements. The performance of the model was assessed with respect to its calibration plot and clinical discrimination in the primary and validation cohorts.Results: Nine radiomics features extracted from an initial set of 485, predominantly reflecting lesion heterogeneity, combined with lesion length, patient sex, and EDSS, were selected to build the model for differentiating MS and NMOSD. The areas under the ROC curves (AUC) for differentiating the two diseases were 0.8808 and 0.7115, for the primary and validation cohort, respectively. This model demonstrated good calibration (C-index was 0.906 and 0.802 in primary and validation cohort).Conclusions: A validated nomogram that incorporates the radiomic signature of spinal cord lesions, as well as cord lesion length, sex, and EDSS score, can usefully differentiate MS and NMOSD.Key Points: • Radiomic features of spinal cord lesions in MS and NMOSD were different. • Radiomic signatures can capture pathological alterations and help differentiate MS and NMOSD. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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