Characterization of focal liver lesions using the stretched exponential model: comparison with monoexponential and biexponential diffusion-weighted magnetic resonance imaging.
Objective: To compare the stretched exponential model of diffusion-weighted imaging (DWI) with monoexponential and biexponential models in terms of the ability to characterize focal liver lesions (FLLs).Methods: This retrospective study included 180 patients with FLLs who underwent magnetic resonanc...
| Publicado en: | European Radiology Vol. 29; no. 9; pp. 5111 - 5121 |
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| Autores principales: | , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Sep2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=137908425&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 137908425 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Sep2019 vid: 29 iid: 9 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 137908425 137908425 NLM30796578 137908425 10.1007/s00330-019-06048-4 NLM30796578 137908425 ppf: 5111 ppct: 10 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Characterization of focal liver lesions using the stretched exponential model: comparison with monoexponential and biexponential diffusion-weighted magnetic resonance imaging. aug: au: Kim, Hyung Cheol Seo, Nieun Chung, Yong Eun Park, Mi-Suk Choi, Jin-Young Kim, Myeong-Jin affil: Department of Radiology, Severance Hospital, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, 03722, Seoul, South Korea sug: subj: Magnetic Resonance Imaging Methods Liver Diseases Diagnosis Liver Human Diagnosis, Differential Female Retrospective Design Reproducibility of Results Adult ROC Curve Middle Age Aged Male Validation Studies Comparative Studies Evaluation Research Multicenter Studies Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years Female Male ab: Objective: To compare the stretched exponential model of diffusion-weighted imaging (DWI) with monoexponential and biexponential models in terms of the ability to characterize focal liver lesions (FLLs).Methods: This retrospective study included 180 patients with FLLs who underwent magnetic resonance imaging including DWI with nine b values at 3.0 T. The distributed diffusion coefficient (DDC) and intravoxel diffusion heterogeneity index (α) from a stretched exponential model; true diffusion coefficient (Dt), pseudo-diffusion coefficient (Dp), and perfusion fraction (f) from a biexponential model; and apparent diffusion coefficient (ADC) were calculated for each lesion. Diagnostic performances of the parameters were assessed through receiver operating characteristic (ROC) analysis. For 20 patients with treated hepatic metastases, the correlation between the DWI parameters and the percentage of tumor necrosis on pathology was evaluated using the Spearman correlation coefficient.Results: DDC had the highest area under the ROC curve (AUC, 0.905) for differentiating malignant from benign lesions, followed by Dt (0.903) and ADC (0.866), without significant differences among them (DDC vs. Dt, p = 0.946; DDC vs. ADC, p = 0.157). For distinguishing hypovascular from hypervascular lesions, and hepatocellular carcinoma from metastasis, f had a significantly higher AUC than the other DWI parameters (p < 0.05). The α had the strongest correlation with the degree of tumor necrosis (ρ = 0.655, p = 0.002).Conclusion: The DDC from stretched exponential model of DWI demonstrated excellent diagnostic performance for differentiating malignant from benign FLLs. The α is promising for evaluating the degree of necrosis in treated metastases.Key Points: • The stretched exponential DWI model is valuable for characterizing focal liver lesions. • The DDC from stretched exponential model shows excellent performance for differentiating malignant from benign focal liver lesions. • The α from stretched exponential model is promising for evaluating the degree of necrosis in hepatic metastases after chemotherapy. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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