Increased Lacrimal Fluid Level of HMGB1 in Vernal Keratoconjunctivitis.
Purpose: The aim of the present prospective study was to evaluate the lacrimal fluid concentration of HMGB1 in young patients affected by Vernal Keratoconjunctivitis (VKC) compared to a control group of healthy subjects of same age. Methods: Tear fluids was collected in a group of VKC patients and c...
| Published in: | Ocular Immunology & Inflammation Vol. 27; no. 5; pp. 808 - 813 |
|---|---|
| Main Authors: | , , , , , , , , , |
| Format: | research tables/charts Journal Article |
| Published: |
Taylor & Francis Ltd
2019
|
| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=138027078&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 138027078 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09273948 EIG jtl: Ocular Immunology & Inflammation issn: 09273948 maglogo: Y pubinfo: dt: 2019 vid: 27 iid: 5 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 138027078 138027078 NLM29847189 138027078 10.1080/09273948.2018.1467465 NLM29847189 138027078 ppf: 808 ppct: 5 formats: tig: atl: Increased Lacrimal Fluid Level of HMGB1 in Vernal Keratoconjunctivitis. aug: au: Caputo, Roberto Pasti, Mattia de Libero, Cinzia Mori, Francesca Barni, Simona Danti, Gioia Buonvicino, Daniela Urru, Matteo Chiarugi, Alberto Pucci, Neri affil: Department of Pediatric Ophthalmology, AOU Meyer, Florence, Italy sug: subj: Lacrimal Apparatus Metabolism Conjunctivitis, Allergic Metabolism Proteins Metabolism Child Prospective Studies Female Enzyme-Linked Immunosorbent Assay Cross Sectional Studies Male Adolescence Tears Metabolism Case Control Studies Human Child: 6-12 years Adolescent: 13-18 years Female Male ab: Purpose: The aim of the present prospective study was to evaluate the lacrimal fluid concentration of HMGB1 in young patients affected by Vernal Keratoconjunctivitis (VKC) compared to a control group of healthy subjects of same age. Methods: Tear fluids was collected in a group of VKC patients and compared to a control group of healthy subjects. HMGB1 concentration was measured using the HMGB1 ELISA II test both in VCK and control subjects. Results: The mean concentration of HMGB1 in tear fluids of 45 VKC patients was 0,977 ± 0,72 ng/ml whereas in the control group was 0,24 ± 0,25 ng/ml and the difference was statistically significant (p = 0,000106) Conclusion: The concentration of HMGB1 in VCK patients was found to be significantly increased, suggesting a possible role of this protein in the inflammatory mechanism of VKC. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|