Normal T1 relaxometry and extracellular volume of the pancreas in subjects with no pancreas disease: correlation with age and gender.
Objective: Determine normal T1 and extracellular volume (ECV) of the pancreas in subjects with no pancreas disease and correlate with age and gender. Subjects and methods: We imaged 120 healthy subjects (age range 20–78 years) who are on annual screening with MRI/MRCP for the possibility of pancreat...
| Publicado en: | Abdominal Radiology Vol. 44; no. 9; pp. 3133 - 3139 |
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| Autores principales: | , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Sep2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=138030419&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 138030419 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 2366004X JT14 jtl: Abdominal Radiology issn: 2366004X maglogo: N pubinfo: dt: Sep2019 vid: 44 iid: 9 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 138030419 143963086 10.1007/s00261-019-02071-7 138030419 ppf: 3133 ppct: 6 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Normal T1 relaxometry and extracellular volume of the pancreas in subjects with no pancreas disease: correlation with age and gender. aug: au: Tirkes, Temel Mitchell, Jacob R. Li, Liang Zhao, Xuandong Lin, Chen affil: Department of Radiology and Imaging Sciences, Indiana University School of Medicine, 550 N. University Blvd. Suite 0663, 46202, Indianapolis, IN, USA sug: ab: Objective: Determine normal T1 and extracellular volume (ECV) of the pancreas in subjects with no pancreas disease and correlate with age and gender. Subjects and methods: We imaged 120 healthy subjects (age range 20–78 years) who are on annual screening with MRI/MRCP for the possibility of pancreatic cancer. Subjects had a predisposition to develop pancreatic cancer, but no history of pancreas disease or acute symptoms. Equal number (n = 60) of subjects were scanned on either 1.5 T or 3 T scanner using dual flip angle spoiled gradient echo technique incorporating fat suppression and correction for B1 field inhomogeneity. Optimization of imaging parameters was performed using a T1 phantom. ECV was calculated using pre- and post-contrast T1 of the pancreas and plasma. Regression analysis and Mann–Whitney tests were used for statistical analysis. Results: Median T1 on 1.5 T was 654 ms (IQR 608–700); median T1 on 3 T was 717 ms (IQR 582–850); median ECV on 1.5 T was 0.28 (IQR 0.21–0.33), and median ECV on 3 T was 0.25 (IQR 0.19–0.28). Age had a mild positive correlation with T1 (r = 0.24, p = 0.009), but not with ECV (r = 0.06, p = 0.54). T1 and ECV were similar in both genders (p > 0.05). Conclusion: This study measured the median T1 and ECV of the pancreas in subjects with no pancreas disease. Pancreas shows longer T1 relaxation times in older population, whereas extracellular fraction remains unchanged. Median T1 values were different between two magnet strengths; however, no difference was seen between genders and ECV fractions. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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