Impairments in reinforcement learning do not explain enhanced habit formation in cocaine use disorder.
Rationale: Drug addiction has been suggested to develop through drug-induced changes in learning and memory processes. Whilst the initiation of drug use is typically goal-directed and hedonically motivated, over time, drug-taking may develop into a stimulus-driven habit, characterised by persistent...
| Publicado en: | Psychopharmacology Vol. 236; no. 8; pp. 2359 - 2372 |
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| Autores principales: | , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Aug2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=138109930&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 138109930 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00333158 EJD jtl: Psychopharmacology issn: 00333158 maglogo: N pubinfo: dt: Aug2019 vid: 236 iid: 8 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 138109930 10.1007/s00213-019-05330-z 138109930 ppf: 2359 ppct: 13 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Impairments in reinforcement learning do not explain enhanced habit formation in cocaine use disorder. aug: au: Lim, T. V. Cardinal, R. N. Savulich, G. Jones, P. S. Moustafa, A. A. Robbins, T. W. Ersche, K. D. affil: Departments of Psychiatry, Psychology and Clinical Neurosciences, University of Cambridge, Herchel Smith Building for Brain & Mind Sciences, Cambridge Biomedical Campus, CB2 0SZ, Cambridge, UK sug: ab: Rationale: Drug addiction has been suggested to develop through drug-induced changes in learning and memory processes. Whilst the initiation of drug use is typically goal-directed and hedonically motivated, over time, drug-taking may develop into a stimulus-driven habit, characterised by persistent use of the drug irrespective of the consequences. Converging lines of evidence suggest that stimulant drugs facilitate the transition of goal-directed into habitual drug-taking, but their contribution to goal-directed learning is less clear. Computational modelling may provide an elegant means for elucidating changes during instrumental learning that may explain enhanced habit formation. Objectives: We used formal reinforcement learning algorithms to deconstruct the process of appetitive instrumental learning and to explore potential associations between goal-directed and habitual actions in patients with cocaine use disorder (CUD). Methods: We re-analysed appetitive instrumental learning data in 55 healthy control volunteers and 70 CUD patients by applying a reinforcement learning model within a hierarchical Bayesian framework. We used a regression model to determine the influence of learning parameters and variations in brain structure on subsequent habit formation. Results: Poor instrumental learning performance in CUD patients was largely determined by difficulties with learning from feedback, as reflected by a significantly reduced learning rate. Subsequent formation of habitual response patterns was partly explained by group status and individual variation in reinforcement sensitivity. White matter integrity within goal-directed networks was only associated with performance parameters in controls but not in CUD patients. Conclusions: Our data indicate that impairments in reinforcement learning are insufficient to account for enhanced habitual responding in CUD. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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