Moral decision making under modafinil: a randomized placebo-controlled double-blind crossover fMRI study.
Rationale: Modafinil is increasingly used by healthy humans as a neuroenhancer in order to improve cognitive functioning. Research on the effects of modafinil on cognition yielded most consistent findings for complex tasks relying on the prefrontal cortex (PFC). Objectives: The present randomized pl...
| Publicado en: | Psychopharmacology Vol. 236; no. 9; pp. 2747 - 2760 |
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| Autores principales: | , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Sep2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=138109948&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 138109948 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00333158 EJD jtl: Psychopharmacology issn: 00333158 maglogo: N pubinfo: dt: Sep2019 vid: 236 iid: 9 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 138109948 143947072 10.1007/s00213-019-05250-y 138109948 ppf: 2747 ppct: 13 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Moral decision making under modafinil: a randomized placebo-controlled double-blind crossover fMRI study. aug: au: Ngo, Thao Ghio, Marta Kuchinke, Lars Roser, Patrik Bellebaum, Christian affil: Department of Biological Psychology, Institute for Experimental Psychology, Heinrich Heine University, Düsseldorf, Germany sug: ab: Rationale: Modafinil is increasingly used by healthy humans as a neuroenhancer in order to improve cognitive functioning. Research on the effects of modafinil on cognition yielded most consistent findings for complex tasks relying on the prefrontal cortex (PFC). Objectives: The present randomized placebo-controlled double-blind crossover study aimed to investigate the effect of a single dose of modafinil (200 mg) on everyday moral decision making and its neural correlates, which have been linked to the ventro- and dorsomedial PFC. Methods: Healthy male study participants were presented with short stories describing everyday moral or neutral dilemmas. Each moral dilemma required a decision between a personal desire and a moral standard, while the neutral dilemmas required decisions between two personal desires. The participants underwent this task twice, once under the influence of modafinil and once under placebo. Brain activity associated with the processing of the dilemmas was assessed by means of functional magnetic resonance imaging. Results: For the processing of moral vs. neutral dilemmas, activations were found in a network of brain regions linked to social cognitive processes including, among others, the bilateral medial PFC, the insula, and the precuneus. Modafinil was found to increase the number of moral decisions and had no effect on brain activity associated with dilemma processing. Exploratory analyses revealed reduced response-locked activity in the dorsomedial PFC for moral compared to neutral dilemmas under modafinil, but not under placebo. Conclusions: The results are discussed in terms of altered predictions of others' emotional states under modafinil, possibly due to higher processing efficiency. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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