Mortality among patients due to adverse drug reactions that occur following hospitalisation: a meta-analysis.
Purpose: To estimate the prevalence of mortality among patients that develop adverse drug reactions during hospitalisation (ADRIn), to examine heterogeneity through subgroup analysis and to identify system-organ class (SOC) and their causative drugs. Methods: Two investigators searched PubMed, Googl...
| Publicado en: | European Journal of Clinical Pharmacology Vol. 75; no. 9; pp. 1293 - 1308 |
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| Autores principales: | , |
| Formato: | research systematic review tables/charts Journal Article |
| Publicado: |
Springer Nature
Sep2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=138111100&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 138111100 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00316970 NP9 jtl: European Journal of Clinical Pharmacology issn: 00316970 maglogo: N pubinfo: dt: Sep2019 vid: 75 iid: 9 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 138111100 138111100 143962246 138111100 10.1007/s00228-019-02702-4 138111100 ppf: 1293 ppct: 15 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Mortality among patients due to adverse drug reactions that occur following hospitalisation: a meta-analysis. aug: au: Patel, Parvati B. Patel, Tejas K. affil: Department of Pharmacology, GMERS Medical College, Gotri, 390021, Vadodara, Gujarat, India sug: subj: Adverse Drug Event Adverse Effects Hospital Mortality Etiology Hospital Mortality Epidemiology Hospitalization Human Meta Analysis Systematic Review PubMed Internal Medicine Intensive Care Units Intensive Care, Neonatal Intensive Care Units, Pediatric Gastrointestinal Diseases Risk Assessment Lymphatic Diseases Kidney Diseases Urologic Diseases Fibrinolytic Agents Adverse Effects Antiinflammatory Agents, Non-Steroidal Adverse Effects Gastrointestinal Hemorrhage Chemically Induced Antineoplastic Agents Adverse Effects Hematologic Diseases Chemically Induced Age Factors ab: Purpose: To estimate the prevalence of mortality among patients that develop adverse drug reactions during hospitalisation (ADRIn), to examine heterogeneity through subgroup analysis and to identify system-organ class (SOC) and their causative drugs. Methods: Two investigators searched PubMed, Google Scholar and related bibliography for studies reporting ADRIn-related mortality data. The primary outcome was to compute overall prevalence of fatal ADRIn (95% CI) using double arcsine method. We explored the heterogeneity (I2) in its estimation based on study design, study population and data collection methods. The secondary outcomes were the pattern of fatal reactions and their causative drugs. PROSPERO register number—CRD42018090331. Results: Out of 349 full text assessed, 48 studies satisfying the selection criteria were included. The fatal ADRIn prevalence was 0.11% (95% CI 0.06–0.18%; I2 = 93%). The fatal ADRIn prevalence ranged from 0.03% (I2 = 0%) in all ages to 0.27% (I2 = 90%) in elderly population studies. Elderly studies varied for all study characteristics. Among study wards, a higher trend of prevalence was observed in 'internal medicine and ICU' (0.46%, I2 = 51%) and 'neonatal/paediatric ward and ICU' (0.34%, I2 = 58%) studies. The commonly involved SOC were 'gastrointestinal disorders' (28.79%), 'blood and lymphatic system disorders' (19.69%) and 'renal and urinary disorders' (13.64%). Most commonly observed causative drug-fatal ADRIn pairs were antithrombotics and nonsteroidal anti-inflammatory drugs induced gastrointestinal bleeding, and antineoplastic agents induced cytopenia. Conclusion: ADRIn is an important cause of mortality. Age groups and study wards have important influence on prevalence of fatal ADRIn and its heterogeneity across studies. Few class drugs contribute to sizable proportion of ADRIn-related mortality. pubtype: Academic Journal doctype: meta analysis research systematic review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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