Problems with extracellular recording of electrical activity in gastrointestinal muscle.
Motility patterns of the gastrointestinal tract are important for efficient processing of nutrients and waste. Peristalsis and segmentation are based on rhythmic electrical slow waves that generate the phasic contractions fundamental to gastrointestinal motility. Slow waves are generated and propaga...
| Published in: | Nature Reviews Gastroenterology & Hepatology Vol. 13; no. 12; pp. 731 - 742 |
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| Main Authors: | , , |
| Format: | Journal Article |
| Published: |
Springer Nature
Dec2016
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=138112762&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 138112762 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 17595045 8UU3 jtl: Nature Reviews Gastroenterology & Hepatology issn: 17595045 maglogo: N pubinfo: dt: Dec2016 vid: 13 iid: 12 pid: 2579 pub: Springer Nature place: Dordrecht, <Blank> artinfo: ui: 138112762 10.1038/nrgastro.2016.161 138112762 ppf: 731 ppct: 11 formats: tig: atl: Problems with extracellular recording of electrical activity in gastrointestinal muscle. aug: au: Sanders, Kenton M. Ward, Sean M. Hennig, Grant W. affil: Department of Physiology and Cell Biology, University of Nevada, Reno School of Medicine, Anderson Medical Sciences, Reno, Nevada 89557, USA. sug: ab: Motility patterns of the gastrointestinal tract are important for efficient processing of nutrients and waste. Peristalsis and segmentation are based on rhythmic electrical slow waves that generate the phasic contractions fundamental to gastrointestinal motility. Slow waves are generated and propagated actively by interstitial cells of Cajal (ICC), and these events conduct to smooth muscle cells to elicit excitation–contraction coupling. Extracellular electrical recording has been utilized to characterize slow-wave generation and propagation and abnormalities that might be responsible for gastrointestinal motility disorders. Electrode array recording and digital processing are being used to generate data for models of electrical propagation in normal and pathophysiological conditions. Here, we discuss techniques of extracellular recording as applied to gastrointestinal organs and how mechanical artefacts might contaminate these recordings and confound their interpretation. Without rigorous controls for movement, current interpretations of extracellular recordings might ascribe inaccurate behaviours and electrical anomalies to ICC networks and gastrointestinal muscles, bringing into question the findings and validity of models of gastrointestinal electrophysiology developed from these recordings. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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