Armillariella Oral Solution Ameliorates Small Intestinal Damage in a Mouse Model of Chemotherapy-Induced Mucositis.
Background: Armillariella oral solution (AOS) shows therapeutic effect on gastrointestinal disorders. We aimed to investigate the potential efficacy of AOS on chemotherapy-induced intestinal mucositis in mice. Methods: Intestinal mucositis was induced in C57BL/6 mice by daily intraperitoneal injecti...
| Publicado en: | Nutrition & Cancer Vol. 71; no. 7; pp. 1142 - 1153 |
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| Autores principales: | , , , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Taylor & Francis Ltd
2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=138226033&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 138226033 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01635581 7MS jtl: Nutrition & Cancer issn: 01635581 maglogo: N pubinfo: dt: 2019 vid: 71 iid: 7 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 138226033 138226033 138226033 10.1080/01635581.2019.1599029 138226033 ppf: 1142 ppct: 11 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Armillariella Oral Solution Ameliorates Small Intestinal Damage in a Mouse Model of Chemotherapy-Induced Mucositis. aug: au: Wenqin, Dong Yaodong, Zhu Wanji, Song Fengli, Zhang Li, Su Haili, Jiang Ping, Li Mei, Zhang affil: Department of Chinese Integrated Medicine Oncology, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province, China sug: subj: Antibiotics, Antifungal Therapeutic Use Administration, Oral Antibiotics, Antifungal Administration and Dosage Chemotherapy, Cancer Adverse Effects Mucositis, Gastrointestinal Chemically Induced Intestine, Small Pathology Mucositis, Gastrointestinal Prevention and Control Animal Studies Mice Models, Biological Treatment Outcomes Administration, Intraperitoneal Bifidobacterium Lactobacillus Histological Techniques Methods Gene Expression Evaluation Tumor Markers, Biological Caspases Analysis Leucine Analysis Antigens, Tumor Analysis Apoptosis Evaluation Severity of Illness Diarrhea Weight Loss ab: Background: Armillariella oral solution (AOS) shows therapeutic effect on gastrointestinal disorders. We aimed to investigate the potential efficacy of AOS on chemotherapy-induced intestinal mucositis in mice. Methods: Intestinal mucositis was induced in C57BL/6 mice by daily intraperitoneal injection of 5-FU (50 mg/kg) for 7 days. Effects of AOS (at 1, 5, and 10 mL/kg), or combined Bifidobacterium and Lactobacillus (CBL, 450 mg/kg) on the accompanying morphometry and histology, expression of Ki-67, caspase-3, Lgr5 and apoptosis of intestinal crypt cells were assessed. Results: Continuous administration of 5-FU to mice caused severe intestinal mucositis, which was histologically characterized by the destruction of intestinal crypts and shortening of villi, accompanied by diarrhea and body weight loss. Daily AOS administration dose-dependently reduced the severity of intestinal mucositis, diarrhea and body weight loss. Similar beneficial effects were observed with CBL. The expression of Ki-67 and Lgr5 decreased and the expression of caspase-3, and the number of apoptotic cells increased 24 h after the first 5-FU administration (P < 0.05), and these responses were significantly reduced by AOS treatment (P < 0.05, at 5 or 10 mL/kg). Conclusions: AOS can alleviate 5-FU-induced mucositis in mice via increasing Lgr5 expression and suppressing apoptotic responses in the intestinal crypt cells. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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