Association of OXTR rs53576 with the Developmental Trajectories of Callous-Unemotional Traits and Stressful Life Events in 3- to 9-Year-Old Community Children.
The objective was to obtain developmental trajectories combining callous-unemotional traits and the number of stressful life-events between ages 3 and 9 years and to ascertain their association with the polymorphism rs53576 at the Oxytocin Receptor gene (OXTR). A total of 377 children were assessed...
| Publicado en: | Journal of Abnormal Child Psychology Vol. 47; no. 10; pp. 1651 - 1663 |
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| Autores principales: | , , , , , |
| Formato: | journal article |
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Springer Nature
Oct2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=138395397&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 138395397 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 00910627 ACP jtl: Journal of Abnormal Child Psychology issn: 00910627 maglogo: N pubinfo: dt: Oct2019 vid: 47 iid: 10 pid: 237 pub: Springer Nature artinfo: ui: 138395397 10.1007/s10802-019-00548-z ppf: 1651 ppct: 12 formats: tig: atl: Association of OXTR rs53576 with the Developmental Trajectories of Callous-Unemotional Traits and Stressful Life Events in 3- to 9-Year-Old Community Children. aug: au: Ezpeleta, Lourdes Penelo, Eva de la Osa, Núria Navarro, J. Blas Fañanás, Lourdes Fatjó-Vilas, Mar affil: Unitat d'Epidemiologia i de Diagnòstic en Psicopatologia del Desenvolupament, Barcelona, Spain Departament de Psicologia Clínica i de la Salut, Edifici B, Universitat Autònoma de Barcelona, 08193 Bellaterra, Barcelona, Spain Departament de Psicobiologia i Metodologia de les Ciències de la Salut, Universitat Autònoma de Barcelona, Barcelona, Spain Departament de Biologia Evolutiva, Ecologia i Ciències Ambientals, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Institut de Biomedicina de la Universitat de Barcelona (IBUB), Barcelona, Spain FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain su: Life change events Children Individual differences Oxytocin receptors Parallel processing sug: subj: Life change events Children Individual differences Oxytocin receptors Parallel processing keyword: Callous-unemotional Developmental trajectories Life events OXTR rs53576 Callous-unemotional Developmental trajectories Life events OXTR rs53576 ab: The objective was to obtain developmental trajectories combining callous-unemotional traits and the number of stressful life-events between ages 3 and 9 years and to ascertain their association with the polymorphism rs53576 at the Oxytocin Receptor gene (OXTR). A total of 377 children were assessed yearly from ages 3 to 9 years. Latent class growth analysis for parallel processes was used to identify distinct trajectories for callous-unemotional traits (assessed using the Inventory of Callous-Unemotional Traits, ICU) and number of stressful life-events, and then the influence of being an A allele carrier on class membership was included with OXTR genotypes as a binary time-invariant predictor, following a 3-step approach. A 3-class model showed the highest entropy (.859) and adequate posterior probabilities of class membership (≥.884). Class 1 (n = 226, 59.9%) included children with low and stable ICU scores and low and descending stressful life-events; class 2 (n = 127, 33.7%) included children with high and ascending ICU scores and low and slightly descending stressful life-events; and class 3 (n = 24, 6.4%) included children with persistently high profiles both for ICU scores and stressful life-events. Carrying an A allele (genotypes GA/AA) increased the odds of pertaining to class 3 (high and persistent ICU scores and stressful life-events) as opposed to class 2 (OR = 4.27, p = 0.034) or class 1 (OR = 3.81, p = 0.042). The results suggest the importance of considering callous-unemotional traits and stressful life-events in conjunction. In addition, the genetic variability of OXTR (rs53576) may help to understand individual differences in early development. pubtype: Academic Journal doctype: journal article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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