Non-invasive assessment of glioma microstructure using VERDICT MRI: correlation with histology.
Purpose: This prospective study evaluated the use of vascular, extracellular and restricted diffusion for cytometry in tumours (VERDICT) MRI to investigate the tissue microstructure in glioma. VERDICT-derived parameters were correlated with both histological features and tumour subtype and were also...
| Published in: | European Radiology Vol. 29; no. 10; pp. 5559 - 5567 |
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| Main Authors: | , , , , , , , , , , , , |
| Format: | diagnostic images pictorial research tables/charts Journal Article |
| Published: |
Springer Nature
Oct2019
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=138395914&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 138395914 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Oct2019 vid: 29 iid: 10 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 138395914 138395914 144046695 NLM30888488 138395914 10.1007/s00330-019-6011-8 NLM30888488 138395914 ppf: 5559 ppct: 8 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Non-invasive assessment of glioma microstructure using VERDICT MRI: correlation with histology. aug: au: Zaccagna, Fulvio Riemer, Frank Priest, Andrew N. McLean, Mary A. Allinson, Kieren Grist, James T. Dragos, Carmen Matys, Tomasz Gillard, Jonathan H. Watts, Colin Price, Stephen J. Graves, Martin J. Gallagher, Ferdia A. affil: Department of Radiology, School of Clinical Medicine, University of Cambridge, Box 218, Cambridge Biomedical Campus, CB2 0QQ, Cambridge, UK sug: subj: Glioma Brain Neoplasms Glioma Pathology Middle Age Male Adult Pilot Studies Prospective Studies Reproducibility of Results Neoplasm Grading Aged Magnetic Resonance Angiography Methods Magnetic Resonance Imaging Methods Young Adult Female Brain Neoplasms Pathology Human Middle Aged: 45-64 years Adult: 19-44 years Aged: 65+ years Male Female ab: Purpose: This prospective study evaluated the use of vascular, extracellular and restricted diffusion for cytometry in tumours (VERDICT) MRI to investigate the tissue microstructure in glioma. VERDICT-derived parameters were correlated with both histological features and tumour subtype and were also used to explore the peritumoural region.Methods: Fourteen consecutive treatment-naïve patients (43.5 years ± 15.1 years, six males, eight females) with suspected glioma underwent diffusion-weighted imaging including VERDICT modelling. Tumour cell radius and intracellular and combined extracellular/vascular volumes were estimated using a framework based on linearisation and convex optimisation. An experienced neuroradiologist outlined the peritumoural oedema, enhancing tumour and necrosis on T2-weighted imaging and contrast-enhanced T1-weighted imaging. The same regions of interest were applied to the co-registered VERDICT maps to calculate the microstructure parameters. Pathology sections were analysed with semi-automated software to measure cellularity and cell size.Results: VERDICT parameters were successfully calculated in all patients. The imaging-derived results showed a larger intracellular volume fraction in high-grade glioma compared to low-grade glioma (0.13 ± 0.07 vs. 0.08 ± 0.02, respectively; p = 0.05) and a trend towards a smaller extracellular/vascular volume fraction (0.88 ± 0.07 vs. 0.92 ± 0.04, respectively; p = 0.10). The conventional apparent diffusion coefficient was higher in low-grade gliomas compared to high-grade gliomas, but this difference was not statistically significant (1.22 ± 0.13 × 10-3 mm2/s vs. 0.98 ± 0.38 × 10-3 mm2/s, respectively; p = 0.18).Conclusion: This feasibility study demonstrated that VERDICT MRI can be used to explore the tissue microstructure of glioma using an abbreviated protocol. The VERDICT parameters of tissue structure correlated with those derived on histology. The method shows promise as a potential test for diagnostic stratification and treatment response monitoring in the future.Key Points: • VERDICT MRI is an advanced diffusion technique which has been correlated with histopathological findings obtained at surgery from patients with glioma in this study. • The intracellular volume fraction measured with VERDICT was larger in high-grade tumours compared to that in low-grade tumours. • The results were complementary to measurements from conventional diffusion-weighted imaging, and the technique could be performed in a clinically feasible timescale. pubtype: Academic Journal doctype: diagnostic images pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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