IVIM improves preoperative assessment of microvascular invasion in HCC.
Purpose: To prospectively evaluate the potential role of intravoxel incoherent motion (IVIM) and conventional radiologic features for preoperative prediction of microvascular invasion (MVI) in patients with hepatocellular carcinoma (HCC).Methods: Institutional review board approval and written infor...
| Publicado en: | European Radiology Vol. 29; no. 10; pp. 5403 - 5415 |
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| Autores principales: | , , , , , , , , |
| Formato: | diagnostic images equations & formulas research tables/charts Journal Article |
| Publicado: |
Springer Nature
Oct2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=138395933&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 138395933 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Oct2019 vid: 29 iid: 10 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 138395933 138395933 144088130 NLM30877465 138395933 10.1007/s00330-019-06088-w NLM30877465 138395933 ppf: 5403 ppct: 12 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: IVIM improves preoperative assessment of microvascular invasion in HCC. aug: au: Wei, Yi Huang, Zixing Tang, Hehan Deng, Liping Yuan, Yuan Li, Jiaxing Wu, Dongbo Wei, Xiaocheng Song, Bin affil: Department of Radiology, West China Hospital, Sichuan University, 610041, Chengdu, China sug: subj: Carcinoma, Hepatocellular Liver Neoplasms Pathology Liver Neoplasms Carcinoma, Hepatocellular Pathology Neoplasm Invasiveness Male Blood Vessels Pathology Blood Vessels Middle Age Preoperative Care Methods Logistic Regression Liver Neoplasms Surgery Odds Ratio Prospective Studies Magnetic Resonance Imaging Methods Aged Adult Carcinoma, Hepatocellular Surgery ROC Curve Motion Observer Bias Female Image Interpretation, Computer Assisted Methods Human Middle Aged: 45-64 years Aged: 65+ years Adult: 19-44 years Male Female ab: Purpose: To prospectively evaluate the potential role of intravoxel incoherent motion (IVIM) and conventional radiologic features for preoperative prediction of microvascular invasion (MVI) in patients with hepatocellular carcinoma (HCC).Methods: Institutional review board approval and written informed consent were obtained for this study. A cohort comprising 115 patients with 135 newly diagnosed HCCs between January 2016 and April 2017 were evaluated. Two radiologists independently reviewed the radiologic features and the apparent diffusion coefficient (ADC), true diffusion coefficient (D), pseudodiffusion coefficient (D*), and pseudodiffusion component fraction (f) were also measured. Interobserver agreement was checked and univariate and multivariate logistic regressions were used for screening the risk factors. Receiver operating characteristics (ROC) curve analyses were performed to evaluate the diagnostic performance.Results: Features significantly related to MVI of HCC at univariate analysis were reduced ADC (odds ratio, 0.341; 95% CI, 0.211-0.552; p < 0.001), D (odds ratio, 0.141; 95% CI, 0.067-0.299; p < 0.001), and irregular circumferential enhancement (odds ratio, 9.908; 95% CI, 3.776-25.996; p < 0.001). At multivariate analysis, only D value (odds ratio, 0.096; 95% CI, 0.025-0.364; p < 0.001) was the independent risk factor for MVI of HCC. The mean D value for MVI of HCC showed an area under ROC curves of 0.815 (95% CI, 0.740-0.877).Conclusion: IVIM model-derived D value is superior to ADC measured with mono-exponential model for evaluating the MVI of HCC. Among MR imaging features, tumor margin, enhancement pattern, tumor capsule, and peritumoral enhancement were not predictive for MVI.Key Points: • Diffusion MRI is useful for non-invasively evaluating the microvascular invasion of hepatocellular carcinoma. • IVIM model is advantageous over mono-exponential model for assessing the microvascular invasion of hepatocellular carcinoma. • Decreased D value was the independent risk factor for predicting MVI of HCC. pubtype: Academic Journal doctype: diagnostic images equations & formulas research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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