T2 mapping of the meniscus is a biomarker for early osteoarthritis.
Purpose: To evaluate in vivo T2 mapping as quantitative, imaging-based biomarker for meniscal degeneration in humans, by studying the correlation between T2 relaxation time and degree of histological degeneration as reference standard.Methods: In this prospective validation study, 13 menisci from se...
| Publicado en: | European Radiology Vol. 29; no. 10; pp. 5664 - 5673 |
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| Autores principales: | , , , , , , , , , , , |
| Formato: | diagnostic images pictorial research tables/charts Journal Article |
| Publicado: |
Springer Nature
Oct2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=138395935&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 138395935 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Oct2019 vid: 29 iid: 10 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 138395935 138395935 144079927 NLM30888480 138395935 10.1007/s00330-019-06091-1 NLM30888480 138395935 ppf: 5664 ppct: 9 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: T2 mapping of the meniscus is a biomarker for early osteoarthritis. aug: au: Eijgenraam, Susanne M. Bovendeert, Frans A. T. Verschueren, Joost van Tiel, Jasper Bastiaansen-Jenniskens, Yvonne M. Wesdorp, Marinus A. Nasserinejad, Kazem Meuffels, Duncan E. Guenoun, Jamal Klein, Stefan Reijman, Max Oei, Edwin H. G. affil: Department of Radiology & Nuclear Medicine, Erasmus MC, University Medical Center, Dr. Molewaterplein 40, room Nd-547, 3015 GD, Rotterdam, The Netherlands sug: subj: Magnetic Resonance Imaging Methods Knee Joint Pathology Algorithms Early Diagnosis Osteoarthritis, Knee Diagnosis Male Female Middle Age Reproducibility of Results Menisci, Tibial Pathology Aged Prospective Studies Scales Middle Aged: 45-64 years Aged: 65+ years Male Female ab: Purpose: To evaluate in vivo T2 mapping as quantitative, imaging-based biomarker for meniscal degeneration in humans, by studying the correlation between T2 relaxation time and degree of histological degeneration as reference standard.Methods: In this prospective validation study, 13 menisci from seven patients with radiographic knee osteoarthritis (median age 67 years, three males) were included. Menisci were obtained during total knee replacement surgery. All patients underwent pre-operative magnetic resonance imaging using a 3-T MR scanner which included a T2 mapping pulse sequence with multiple echoes. Histological analysis of the collected menisci was performed using the Pauli score, involving surface integrity, cellularity, matrix organization, and staining intensity. Mean T2 relaxation times were calculated in meniscal regions of interest corresponding with the areas scored histologically, using a multi-slice multi-echo postprocessing algorithm. Correlation between T2 mapping and histology was assessed using a generalized least squares model fit by maximum likelihood.Results: The mean T2 relaxation time was 22.4 ± 2.7 ms (range 18.5-27). The median histological score was 10, IQR 7-11 (range 4-13). A strong correlation between T2 relaxation time and histological score was found (rs = 0.84, CI 95% 0.64-0.93).Conclusion: In vivo T2 mapping of the human meniscus correlates strongly with histological degeneration, suggesting that T2 mapping enables the detection and quantification of early compositional changes of the meniscus in knee OA.Key Points: • Prospective histology-based study showed that in vivo T 2 mapping of the human meniscus correlates strongly with histological degeneration. • Meniscal T 2 mapping allows detection and quantifying of compositional changes, without need for contrast or special MRI hardware. • Meniscal T 2 mapping provides a biomarker for early OA, potentially allowing early treatment strategies and prevention of OA progression. pubtype: Academic Journal doctype: diagnostic images pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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