CT temporal subtraction improves early detection of bone metastases compared to SPECT.
Objectives: To compare observer performance of detecting bone metastases between bone scintigraphy, including planar scan and single-photon emission computed tomography, and computed tomography (CT) temporal subtraction (TS).Methods: Data on 60 patients with cancer who had undergone CT (previous and...
| Published in: | European Radiology Vol. 29; no. 10; pp. 5673 - 5682 |
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| Main Authors: | , , , , , , , , , , , , |
| Format: | research Journal Article |
| Published: |
Springer Nature
Oct2019
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=138395945&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 138395945 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Oct2019 vid: 29 iid: 10 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 138395945 138395945 144052246 NLM30888486 138395945 10.1007/s00330-019-06107-w NLM30888486 138395945 ppf: 5673 ppct: 9 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: CT temporal subtraction improves early detection of bone metastases compared to SPECT. aug: au: Onoue, Koji Nishio, Mizuho Yakami, Masahiro Aoyama, Gakuto Nakagomi, Keita Iizuka, Yoshio Kubo, Takeshi Emoto, Yutaka Akasaka, Thai Satoh, Kiyohide Yamamoto, Hiroyuki Isoda, Hiroyoshi Togashi, Kaori affil: Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate School of Medicine, 54 Kawahara-cho, Shogoin, Sakyo-ku, 606-8507, Kyoto, Japan sug: subj: Bone Neoplasms Diagnosis Early Detection of Cancer Methods Tomography, X-Ray Computed Methods Image Processing, Computer Assisted Methods Tomography, Emission-Computed, Single-Photon Methods Bone Neoplasms Aged Aged, 80 and Over Female Human ROC Curve Adult Middle Age Male Neoplasm Metastasis Validation Studies Comparative Studies Evaluation Research Multicenter Studies Scales Aged: 65+ years Aged, 80 & over Adult: 19-44 years Middle Aged: 45-64 years Female Male ab: Objectives: To compare observer performance of detecting bone metastases between bone scintigraphy, including planar scan and single-photon emission computed tomography, and computed tomography (CT) temporal subtraction (TS).Methods: Data on 60 patients with cancer who had undergone CT (previous and current) and bone scintigraphy were collected. Previous CT images were registered to the current ones by large deformation diffeomorphic metric mapping; the registered previous images were subtracted from the current ones to produce TS. Definitive diagnosis of bone metastases was determined by consensus between two radiologists. Twelve readers independently interpreted the following pairs of examinations: NM-pair, previous and current CTs and bone scintigraphy, and TS-pair, previous and current CTs and TS. The readers assigned likelihood levels to suspected bone metastases for diagnosis. Sensitivity, number of false positives per patient (FPP), and reading time for each pair of examinations were analysed for evaluating observer performance by performing the Wilcoxon signed-rank test. Figure-of-merit (FOM) was calculated using jackknife alternative free-response receiver operating characteristic analysis.Results: The sensitivity of TS was significantly higher than that of bone scintigraphy (54.3% vs. 41.3%, p = 0.006). FPP with TS was significantly higher than that with bone scintigraphy (0.189 vs. 0.0722, p = 0.003). FOM of TS tended to be better than that of bone scintigraphy (0.742 vs. 0.691, p = 0.070).Conclusion: Sensitivity of TS in detecting bone metastasis was significantly higher than that of bone scintigraphy, but still limited to 54%. TS might be superior to bone scintigraphy for early detection of bone metastasis.Key Points: • Computed tomography temporal subtraction was helpful in early detection of bone metastases. • Sensitivity for bone metastasis was higher for computed tomography temporal subtraction than for bone scintigraphy. • Figure-of-merit of computed tomography temporal subtraction was better than that of bone scintigraphy. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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