Persistence of use of prescribed cannabinoid medicines in Manitoba, Canada: a population‐based cohort study.
Background and aims: To estimate prevalence of continuous use (persistence) of prescribed cannabinoid medications for up to 1 year from initial prescription in Manitoba, Canada and predictors of duration of use. Design and setting: A retrospective, population‐based, cohort study using administrative...
| Publicado en: | Addiction Vol. 114; no. 10; pp. 1791 - 1800 |
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| Autores principales: | , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Oct2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=138498285&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 138498285 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09652140 AIO jtl: Addiction issn: 09652140 maglogo: Y pubinfo: dt: Oct2019 vid: 114 iid: 10 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 138498285 138498285 138498285 10.1111/add.14719 138498285 ppf: 1791 ppct: 9 formats: fmt: – @attributes: type: T – @attributes: type: C – @attributes: type: P tig: atl: Persistence of use of prescribed cannabinoid medicines in Manitoba, Canada: a population‐based cohort study. aug: au: Alkabbani, Wajd Marrie, Ruth Ann Bugden, Shawn Alessi‐Severini, Silvia Bolton, James M. Daeninck, Paul Leong, Christine affil: College of Pharmacy, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg Manitoba, Canada sug: subj: Cannabis Canada Prescriptions, Drug Canada Health Services Misuse Canada Treatment Duration Canada Substance Abuse Risk Factors Human Canada Prospective Studies Prevalence Retrospective Design Confidence Intervals Adult Middle Age Socioeconomic Factors Fibromyalgia Diagnosis Odds Ratio Osteoarthritis Diagnosis Substance Use Disorders Diagnosis Neoplasms Diagnosis Persons with Substance Use Disorders Psychosocial Factors Adult: 19-44 years Middle Aged: 45-64 years ab: Background and aims: To estimate prevalence of continuous use (persistence) of prescribed cannabinoid medications for up to 1 year from initial prescription in Manitoba, Canada and predictors of duration of use. Design and setting: A retrospective, population‐based, cohort study using administrative data from the Manitoba Population Research Data Repository located at the Manitoba Centre for Health Policy, Canada. Participants: People without a record of a previous prescription who were prescribed a cannabinoid medication from 1 April 2004 to 1 April 2016 followed for 1 year from the date of first prescription. Measurements Continuous prescribed cannabinoid medication use was defined as use without a gap exceeding 60 days between prescriptions. The primary outcome was prevalence of continuous prescribed cannabinoid medication use for up to 1 year. A secondary outcome was duration of continuous use. Predictors were socio‐demographic characteristics, medical diagnoses and type of cannabinoid medication. Findings Among 5452 new users, 18.1% [95% confidence interval (CI) = 17.08–19.12] were still using cannabinoids at 1 year. Median duration of use was 31 days [interquartile range (IQR) = 25–193]. This was highest for nabilone (33 days, IQR = 25–199) and lowest for nabiximols (20 days, IQR = 7–30). Use was longest among 19–45‐ and 46–64‐year‐old users and those with the highest socio‐economic status. Fibromyalgia [hazard ratio (HR) = 0.89, 95% CI = 0.84–0.95], osteoarthritis (HR = 0.91, 95% CI = 0.82–0.97) and substance use disorder (HR = 0.85, 95% CI = 0.76–0.94) diagnoses were associated with longer use (HR for discontinuation—HR < 1 less discontinuation and longer use). A diagnosis of cancer was associated with shorter use (HR = 2.73, 95% CI = 2.02–3.67). Conclusions: In Manitoba, Canada approximately 18% of people prescribed cannabinoid medication continue using for at least 1 year. Duration of use varies with type of cannabinoid medication, age, socio‐economic status and dagnosis. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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