Mapping correlations of psychological and structural connectome properties of the dataset of the human connectome project with the maximum spanning tree method.
Genome-wide association studies (GWAS) opened new horizons in genomics and medicine by discovering novel genetic factors in numerous health conditions. The analogous analysis of the correlations of large quantities of psychological and brain imaging measures may yield similarly striking results in t...
| Published in: | Brain Imaging & Behavior Vol. 13; no. 5; pp. 1185 - 1193 |
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| Main Authors: | , , |
| Format: | research Journal Article |
| Published: |
Springer Nature
Oct2019
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=138504733&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 138504733 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19317557 3GSC jtl: Brain Imaging & Behavior issn: 19317557 maglogo: N pubinfo: dt: Oct2019 vid: 13 iid: 5 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 138504733 138504733 144191408 NLM30088220 138504733 10.1007/s11682-018-9937-6 NLM30088220 138504733 ppf: 1185 ppct: 8 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Mapping correlations of psychological and structural connectome properties of the dataset of the human connectome project with the maximum spanning tree method. aug: au: Szalkai, Balázs Varga, Bálint Grolmusz, Vince affil: PIT Bioinformatics Group, Eötvös University, H-1117, Budapest, Hungary sug: subj: Brain Mapping Nervous System Image Processing, Computer Assisted Brain Neuropsychological Tests Brain Anatomy and Histology Neural Pathways Magnetic Resonance Imaging Human Validation Studies Comparative Studies Evaluation Research Multicenter Studies ab: Genome-wide association studies (GWAS) opened new horizons in genomics and medicine by discovering novel genetic factors in numerous health conditions. The analogous analysis of the correlations of large quantities of psychological and brain imaging measures may yield similarly striking results in the brain science. Smith et al. (Nat Neurosci. 18(11): 1565-1567, 2015) presented a study of the associations between MRI-detected resting-state functional connectomes and behavioral data, based on the Human Connectome Project's (HCP) data release. Here we analyze the pairwise correlations between 717 psychological-, anatomical- and structural connectome-properties, based also on the Human Connectome Project's 500-subject dataset. For the connectome properties, we have focused on the structural (or anatomical) connectomes, instead of the functional connectomes. For the structural connectome analysis we have computed and publicly deposited structural braingraphs at the site http://braingraph.org . Numerous non-trivial and hard-to-compute graph-theoretical parameters (like minimum bisection width, minimum vertex cover, eigenvalue gap, maximum matching number, maximum fractional matching number) were computed for braingraphs of each subject, gained from the left- and right hemispheres and the whole brain. The correlations of these parameters, as well as other anatomical and behavioral measures were detected and analyzed. For discovering and visualizing the most interesting correlations in the 717 x 717 matrix, we have applied the maximum spanning tree method. Apart from numerous natural correlations, which describe parameters computable or approximable from one another, we have found several significant, novel correlations in the dataset, e.g., between the score of the NIH Toolbox 9-hole Pegboard Dexterity Test and the maximum weight graph theoretical matching in the left hemisphere. We also have found correlations described very recently and independently from the HCP-dataset: e.g., between gambling behavior and the number of the connections leaving the insula: these already known findings independently validate the power of our method. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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