The neural correlates of perceived energy levels in older adults with late-life depression.
Late-life depression is common among older adults. Although white-matter abnormality is highly implicated, the extent to which the corticospinal tract is associated with the pathophysiology of late-life depression is unclear. The current study aims to investigate the white-matter structural integrit...
| Publicado en: | Brain Imaging & Behavior Vol. 13; no. 5; pp. 1397 - 1406 |
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| Autores principales: | , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Oct2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=138504736&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 138504736 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19317557 3GSC jtl: Brain Imaging & Behavior issn: 19317557 maglogo: N pubinfo: dt: Oct2019 vid: 13 iid: 5 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 138504736 138504736 143920652 NLM30159766 10.1007/s11682-018-9940-y NLM30159766 138504736 ppf: 1397 ppct: 9 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: The neural correlates of perceived energy levels in older adults with late-life depression. aug: au: Lam, Charlene L. M. Liu, Ho-Ling Huang, Chih-Mao Wai, Yau-Yau Lee, Shwu-Hua Yiend, Jenny Lin, Chemin Lee, Tatia M. C. affil: State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, Pokfulam, Hong Kong sug: subj: Brain Fatigue Neural Pathways Physiopathology Brain Physiopathology Neural Pathways Depression Physiopathology Depression Diagnosis Brain Pathology Severity of Illness Indices Neuropsychological Tests Female Magnetic Resonance Imaging Male Neural Pathways Pathology Aged Arthritis Impact Measurement Scales Clinical Assessment Tools Scales Aged: 65+ years Female Male ab: Late-life depression is common among older adults. Although white-matter abnormality is highly implicated, the extent to which the corticospinal tract is associated with the pathophysiology of late-life depression is unclear. The current study aims to investigate the white-matter structural integrity of the corticospinal tract and determine its cognitive and functional correlates in older adults with late-life depression. Twenty-eight older adults with clinical depression and 23 healthy age-matched older adults participated in the study. The white matter volume and the white matter hyperintensities (WMHs) of the corticospinal tract, as well as the global WMHs, were measured. Psychomotor processing speed, severity of depression, perceived levels of energy and physical functioning were measured to examine the relationships among the correlates in the depressed participants. The right corticospinal tract volume was significantly higher in depressed older adults relative to healthy controls. Moreover, the right corticospinal tract volume was significantly associated with the overall severity of depression and accounted for 17% of its variance. It further attenuated the relationship between the severity of depression and perceived levels of energy. Our findings suggested that higher volume in the right corticospinal tract is implicated in LLD and may relate to lower perceived levels of energy experienced by older adults with depression. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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