The impact of localized grey matter damage on neighboring connectivity: posterior cortical atrophy and the visual network.
Posterior cortical atrophy (PCA), a localized neurodegenerative syndrome involving the occipito-parietal cortices, can serve as a good model to elaborate on the consequence of a localized damage on the anatomical and functional connectivity within an affected system. Ten PCA patients and 14 aged-mat...
| Publicado en: | Brain Imaging & Behavior Vol. 13; no. 5; pp. 1292 - 1302 |
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| Autores principales: | , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Oct2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=138504748&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 138504748 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19317557 3GSC jtl: Brain Imaging & Behavior issn: 19317557 maglogo: N pubinfo: dt: Oct2019 vid: 13 iid: 5 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 138504748 138504748 144147128 NLM30145717 10.1007/s11682-018-9952-7 NLM30145717 138504748 ppf: 1292 ppct: 10 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: The impact of localized grey matter damage on neighboring connectivity: posterior cortical atrophy and the visual network. aug: au: Glick-Shames, Haya Backner, Yael Bick, Atira Raz, Noa Levin, Netta affil: fMRI lab, Neurology Department, Hadassah-Hebrew University Medical Center, POB 12000, 91120, Jerusalem, Israel sug: subj: Brain Pathology Occipital Lobe Pathology Gray Matter Pathology Parietal Lobe Pathology Neural Pathways Middle Age Female Magnetic Resonance Imaging Neuropsychological Tests Clinical Assessment Tools Impact of Events Scale Middle Aged: 45-64 years Female ab: Posterior cortical atrophy (PCA), a localized neurodegenerative syndrome involving the occipito-parietal cortices, can serve as a good model to elaborate on the consequence of a localized damage on the anatomical and functional connectivity within an affected system. Ten PCA patients and 14 aged-matched controls were enrolled. Structural connectivity was measured via Diffusion Tensor Imaging (DTI) and probabilistic tractography. The optic tracts and radiations and the splenial fibers were delineated and their microstructural properties were evaluated. Functional connectivity was measured by resting state functional MRI (rsfMRI). Voxel-based morphometry (VBM) was used to assess atrophy. Dorsal stream visual functions were tested and correlation between these behavioral data, volume measures, white matter integrity and connectivity were examined. Impaired white matter integrity was evident in patients' optic radiations and occipito-callosal fibers, in the segments located in close proximity to the occipital cortex, suggesting a localized damage. Degeneration did not proceed to the optic tracts, opposing trans-synaptic changes. rsfMRI revealed reduced connectivity within the visual network and between the visual and other related areas such as the frontal eye field. Correlations were found between grey matter volume and spatial perception abilities and between the integrity of the affected fibers and motion perception. White matter involvement in PCA seems to be grey matter dependent. Functional connectivity, on the other hand, showed a more diffuse pattern of damage. Correlations were found between the integrity of the affected fibers and patients' visual abilities suggesting that fiber integrity plays a role in determining behavioral manifestation. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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