Predicting trait-like individual differences in fear of pain in the healthy state using gray matter volume.
Fear of pain (FOP) can be considered as a product of evolution from overstated negative interpretations of pain and sometimes may cause more damage than the actual pain itself. While trait-like measures of FOP have emerged as predictors for the inception and development of chronic pain, its neural u...
| Publicado en: | Brain Imaging & Behavior Vol. 13; no. 5; pp. 1468 - 1474 |
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| Autores principales: | , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Oct2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=138504753&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 138504753 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19317557 3GSC jtl: Brain Imaging & Behavior issn: 19317557 maglogo: N pubinfo: dt: Oct2019 vid: 13 iid: 5 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 138504753 138504753 144186276 NLM30206819 10.1007/s11682-018-9960-7 NLM30206819 138504753 ppf: 1468 ppct: 6 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Predicting trait-like individual differences in fear of pain in the healthy state using gray matter volume. aug: au: Wang, Xiaowan Baeken, Chris Fang, Mengxia Qiu, Jiang Chen, Hong Wu, Guo-Rong affil: Key Laboratory of Cognition and Personality, Faculty of Psychology, Southwest University, Chongqing, China sug: subj: Gray Matter Pathology Limbic System Pathology Fear Frontal Lobe Pathology Pain Magnetic Resonance Imaging Male Female Individuality Brain Pathology Adult Brain Young Adult Adult: 19-44 years Male Female ab: Fear of pain (FOP) can be considered as a product of evolution from overstated negative interpretations of pain and sometimes may cause more damage than the actual pain itself. While trait-like measures of FOP have emerged as predictors for the inception and development of chronic pain, its neural underpinnings are not well understood. To investigate the relationship between gray matter volumes (GMV) and trait-like individual differences in FOP, we analyzed structural magnetic resonance imaging data in a sample of healthy young adults. Regression analysis results showed that individuals with higher FOP scores displayed higher GMV in brain regions important for the regulation of pain and fear. These brain areas include the pregenual anterior cingulate cortex (ACC), the anterior part of the dorsal ACC, the dorsomedial prefrontal cortex, and the adjacent pre-supplementary motor area. Furthermore, cross-validation analysis confirmed that the identified regional GMV offered a reliable neural signature of trait-like FOP. Our findings shed more light on the neuroanatomical architecture of FOP in currently pain-free people, which may be helpful to guide early interventions to prevent FOP from becoming chronic. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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