Convolutional Neural Networks for the Detection and Measurement of Cerebral Aneurysms on Magnetic Resonance Angiography.

Aneurysm size correlates with rupture risk and is important for treatment planning. User annotation of aneurysm size is slow and tedious, particularly for large data sets. Geometric shortcuts to compute size have been shown to be inaccurate, particularly for nonstandard aneurysm geometries. To devel...

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Publicado en:Journal of Digital Imaging Vol. 32; no. 5; pp. 808 - 816
Autores principales: Stember, Joseph N., Chang, Peter, Stember, Danielle M., Liu, Michael, Grinband, Jack, Filippi, Christopher G., Meyers, Philip, Jambawalikar, Sachin
Formato: diagnostic images equations & formulas research tables/charts Journal Article
Publicado: Springer Nature Oct2019
Acceso en línea:Ver este registro en EBSCOhost
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      pub: Springer Nature
      place: New York, New York
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        atl: Convolutional Neural Networks for the Detection and Measurement of Cerebral Aneurysms on Magnetic Resonance Angiography.
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        au:
          Stember, Joseph N.
          Chang, Peter
          Stember, Danielle M.
          Liu, Michael
          Grinband, Jack
          Filippi, Christopher G.
          Meyers, Philip
          Jambawalikar, Sachin
        affil: Radiology, Columbia University Medical Center, 622 West 168th Street, PB 1-301, New York, NY, USA
      sug:
        subj:
          Cerebral Aneurysm Diagnosis
          Cerebral Aneurysm Pathology
          Magnetic Resonance Angiography
          Neural Networks (Computer)
          Human
          Descriptive Statistics
          ROC Curve
          Image Processing, Computer Assisted
      ab: Aneurysm size correlates with rupture risk and is important for treatment planning. User annotation of aneurysm size is slow and tedious, particularly for large data sets. Geometric shortcuts to compute size have been shown to be inaccurate, particularly for nonstandard aneurysm geometries. To develop and train a convolutional neural network (CNN) to detect and measure cerebral aneurysms from magnetic resonance angiography (MRA) automatically and without geometric shortcuts. In step 1, a CNN based on the U-net architecture was trained on 250 MRA maximum intensity projection (MIP) images, then applied to a testing set. In step 2, the trained CNN was applied to a separate set of 14 basilar tip aneurysms for size prediction. Step 1—the CNN successfully identified aneurysms in 85/86 (98.8% of) testing set cases, with a receiver operating characteristic (ROC) area-under-the-curve of 0.87. Step 2—automated basilar tip aneurysm linear size differed from radiologist-traced aneurysm size on average by 2.01 mm, or 30%. The CNN aneurysm area differed from radiologist-derived area on average by 8.1 mm2 or 27%. CNN correctly predicted the area trend for the set of aneurysms. This approach is to our knowledge the first using CNNs to derive aneurysm size. In particular, we demonstrate the clinically pertinent application of computing maximal aneurysm one-dimensional size and two-dimensional area. We propose that future work can apply this to facilitate pre-treatment planning and possibly identify previously missed aneurysms in retrospective assessment.
      pubtype: Academic Journal
      doctype:
        diagnostic images
        equations & formulas
        research
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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