Famotidine versus omeprazole, in combination with amoxycillin and tinidazole, for eradication of Helicobacter pylori infection.
Background: Eradication regimens combining two antibiotics with a proton pump inhibitor have been studied intensively. In contrast, only a few studies have focused on the possible role of H2-receptor antagonists in eradication therapy. The mechanism involved in the synergy between antibiotics and pr...
| Publicado en: | European Journal of Gastroenterology & Hepatology Vol. 13; no. 8; pp. 921 - 927 |
|---|---|
| Autores principales: | , , , , |
| Formato: | clinical trial research randomized controlled trial Journal Article |
| Publicado: |
Lippincott Williams & Wilkins
2001 Aug
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=138561199&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 138561199 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 0954691X 8CE jtl: European Journal of Gastroenterology & Hepatology issn: 0954691X maglogo: N pubinfo: dt: 2001 Aug vid: 13 iid: 8 pid: 5086 pub: Lippincott Williams & Wilkins place: Baltimore, Maryland artinfo: ui: 138561199 138561199 NLM11507356 138561199 10.1097/00042737-200108000-00008 NLM11507356 138561199 ppf: 921 ppct: 6 formats: tig: atl: Famotidine versus omeprazole, in combination with amoxycillin and tinidazole, for eradication of Helicobacter pylori infection. aug: au: Hsu, C C Chen, J J Hu, T H Lu, S N Changchien, C S affil: Division of Gastroenterology, Department of Internal Medicine, Kaohsiung Medical Centre, Chang Gung Memorial Hospital, Tainan, Taiwan sug: subj: Imidazoles Administration and Dosage Penicillins Administration and Dosage Famotidine Administration and Dosage Helicobacter Pylori Amoxicillin Administration and Dosage Enzyme Inhibitors Administration and Dosage Antibiotics Administration and Dosage Omeprazole Administration and Dosage Proton Pump Inhibitors Helicobacter Infections Drug Therapy Histamine H2 Antagonists Administration and Dosage Aged, 80 and Over Peptic Ulcer Drug Therapy Peptic Ulcer Complications Human Omeprazole Adverse Effects Aged Adult Adolescence Helicobacter Infections Complications Male Penicillins Adverse Effects Imidazoles Adverse Effects Enzyme Inhibitors Adverse Effects Peptic Ulcer Diagnosis Female Antibiotics Adverse Effects Histamine H2 Antagonists Adverse Effects Amoxicillin Adverse Effects Famotidine Adverse Effects Middle Age Drug Therapy, Combination Helicobacter Infections Diagnosis Prospective Studies Clinical Trials Validation Studies Comparative Studies Evaluation Research Multicenter Studies Randomized Controlled Trials Impact of Events Scale Aged, 80 & over Aged: 65+ years Adult: 19-44 years Adolescent: 13-18 years Middle Aged: 45-64 years Male Female ab: Background: Eradication regimens combining two antibiotics with a proton pump inhibitor have been studied intensively. In contrast, only a few studies have focused on the possible role of H2-receptor antagonists in eradication therapy. The mechanism involved in the synergy between antibiotics and proton pump inhibitors is still controversial.Objectives: To compare the results of two triple-therapy regimens, different only in the antisecretory drugs used, in patients with Helicobacter pylori infection, and to assess the impact of primary resistance to metronidazole on treatment outcome.Methods: A total of 120 patients with peptic ulcer and non-ulcer dyspepsia were randomly assigned to a 2-week course of either: famotidine 40 mg twice a day, amoxycillin 1 g twice a day and tinidazole 500 mg twice a day (FAT group; n = 60); or omeprazole 20 mg twice a day, amoxycillin 1 g twice a day and tinidazole 500 mg twice a day (OAT group; n = 60). Upper endoscopy was performed prior to treatment and at least 4 weeks after completion of treatment and discontinuation of the antisecretory therapy. H. pylori status was assessed by a biopsy urease test, histology and culture.Results: In the intention-to-treat analysis, eradication of H. pylori was achieved in 48 of the 60 patients (80%; 95% confidence interval: 70-90%) in the FAT group, compared to 50 of the 60 patients (83.3%; 95% confidence interval: 74-93%) in the OAT group. In the per protocol analysis, eradication therapy was achieved in 48 out of 53 patients (90.6%; 95% confidence interval: 83-98%) treated with FAT and 50 out of 57 patients (87.7%; 95% confidence interval: 79-96%) treated with OAT (not significant). The primary metronidazole resistance was present in 28.8% of strains. Overall, per protocol eradication rates in strains resistant and susceptible to metronidazole were 83.3% and 91.3% respectively (P > 0.05).Conclusions: Two-week courses of either high-dose famotidine or omeprazole, both combined with amoxycillin and tinidazole, are equally effective for eradication of H. pylori infection. In a 2-week triple therapy, metronidazole resistance has no significant impact on eradication rates. pubtype: Academic Journal doctype: clinical trial research randomized controlled trial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|