Bleeding peptic ulcers and presence of Helicobacter pylori by various tests: a case-control study.
Background: Virulence factors of Helicobacter pylori are associated with peptic ulcer disease and may be also associated with bleeding peptic ulcers (BPU).Aim: To determine whether H. pylori and/or the cytotoxin-associated gene (cagA) can increase the risk of bleeding in peptic ulcers.Patients: Sixt...
| Publicado en: | European Journal of Gastroenterology & Hepatology Vol. 14; no. 10; pp. 1113 - 1119 |
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| Autores principales: | , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Lippincott Williams & Wilkins
2002 Oct
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=138562674&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 138562674 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 0954691X 8CE jtl: European Journal of Gastroenterology & Hepatology issn: 0954691X maglogo: N pubinfo: dt: 2002 Oct vid: 14 iid: 10 pid: 5086 pub: Lippincott Williams & Wilkins place: Baltimore, Maryland artinfo: ui: 138562674 138562674 NLM12362102 138562674 10.1097/00042737-200210000-00012 NLM12362102 138562674 ppf: 1113 ppct: 6 formats: tig: atl: Bleeding peptic ulcers and presence of Helicobacter pylori by various tests: a case-control study. aug: au: Castillo-Rojas, Gonzalo Ballesteros, M Arturo Ponce de León, Sergio Morales-Espinosa, Rosario Cravioto, Alejandro López-Vidal, Yolanda affil: Universidad Nacional Autónoma de México, Facultad de Medicina, Programa de Inmunología Molecular Microbiana, Edif. de investigación, 4to piso, México DF, CP 04510, México sug: subj: Helicobacter Pylori Duodenal Ulcer Microbiology Antigens, Bacterial Helicobacter Infections Complications Peptic Ulcer Microbiology Bacterial Proteins Analysis Male Prospective Studies Case Control Studies Immunoglobulins Blood Helicobacter Infections Blood Helicobacter Infections RNA RNA Analysis Middle Age Female Human Polymerase Chain Reaction Methods Regression Endoscopy, Gastrointestinal Methods Validation Studies Comparative Studies Evaluation Research Multicenter Studies Clinical Assessment Tools Middle Aged: 45-64 years Male Female ab: Background: Virulence factors of Helicobacter pylori are associated with peptic ulcer disease and may be also associated with bleeding peptic ulcers (BPU).Aim: To determine whether H. pylori and/or the cytotoxin-associated gene (cagA) can increase the risk of bleeding in peptic ulcers.Patients: Sixty-seven patients were studied. Thirty had BPU, 20 had non-bleeding peptic ulcers (NBPU), and 17 were control subjects (NPU).Methods: The prevalence of H. pylori was assessed by the urease fast test, histological examination, serology, and 16S ribosomal RNA and cagA gene amplification by polymerase chain reaction (PCR).Results: Histology and PCR showed greater sensitivity for diagnosis of H. pylori under bleeding circumstances when compared with other tests. Association of H. pylori was greater in the NBPU group (odds ratio [OR] 4.91, P = 0.06) than in the BPU group (OR 1.27, P = NS) when compared with the control group. When the BPU and NBPU groups were compared, H. pylori was found more often in the NBPU group (OR 0.26, P < 0.10 ). The cagA-positive gene showed a similar distribution in the three groups. The titres for anti-CagA immunoglobulin A (IgA) antibodies were higher in NBPU patients (83%) than in BPU or control patients. Furthermore, anti-urease immunoglobulin G (IgG) was detected more frequently among BPU and NBPU patients.Conclusions: NBPU patients had the highest prevalence of H. pylori by PCR. It seems unlikely that either H. pylori or the cagA-positive gene act as significant risk factors for bleeding in peptic ulcers. The lower prevalence of the microorganism among patients who bleed cannot be explained as an artificial finding. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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