Autonomic nervous function in Helicobacter pylori-infected patients with atypical chest pain studied by analysis of heart rate variability.
Objectives: Cardiovascular autonomic nervous system (ANS) activity estimated by analysis of heart rate variability (HRV) was compared in Helicobacter pylori-positive and H. pylori-negative male patients suffering from atypical chest pain to verify the hypothesis that autonomic neural system might be...
| Publicado en: | European Journal of Gastroenterology & Hepatology Vol. 16; no. 5; pp. 451 - 458 |
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| Autores principales: | , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Lippincott Williams & Wilkins
May2004
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=138568797&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 138568797 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 0954691X 8CE jtl: European Journal of Gastroenterology & Hepatology issn: 0954691X maglogo: N pubinfo: dt: May2004 vid: 16 iid: 5 pid: 5086 pub: Lippincott Williams & Wilkins place: Baltimore, Maryland artinfo: ui: 138568797 138568797 NLM15097036 138568797 10.1097/00042737-200405000-00003 NLM15097036 138568797 ppf: 451 ppct: 7 formats: tig: atl: Autonomic nervous function in Helicobacter pylori-infected patients with atypical chest pain studied by analysis of heart rate variability. aug: au: Budzyński, Jacek Kłopocka, Maria Bujak, Robert Swiatkowski, Maciej Pulkowski, Grzegorz Sinkiewicz, Władysław affil: Department of Gastroenterology, Vascular Diseases and Internal Medicine, The Ludwik Rydygier Medical University, Bydgoszcz, Poland sug: subj: Helicobacter Infections Physiopathology Autonomic Nervous System Physiopathology Heart Rate Physiology Helicobacter Pylori Male Adult Electrocardiography, Ambulatory Esophagus Physiopathology Gastric Acidity Determination Exercise Test Manometry Cox Proportional Hazards Model Human Gastric Mucosa Pathology Chest Pain Microbiology Helicobacter Infections Pathology Case Control Studies Signal Processing, Computer Assisted Middle Age Hydrogen-Ion Concentration Validation Studies Comparative Studies Evaluation Research Multicenter Studies Exercise of Self-Care Agency Scale Adult: 19-44 years Middle Aged: 45-64 years Male ab: Objectives: Cardiovascular autonomic nervous system (ANS) activity estimated by analysis of heart rate variability (HRV) was compared in Helicobacter pylori-positive and H. pylori-negative male patients suffering from atypical chest pain to verify the hypothesis that autonomic neural system might be the way linking chronic H. pylori infection with gastrointestinal tract disorders.Methods: We have analysed data obtained from 101 male patients examined in our clinic due to atypical chest pain, without evidence of serious cardiovascular, respiratory and digestive tract or metabolic diseases. In each patient, besides interview and physical examination, were performed: gastroscopy with mucosa biopsy (for urease test and histology), oesophageal pH-metry and manometry, ultrasound abdomen examination, chest X-ray, exercise test on running track, 24-h ECG Holter monitoring with time-domain and frequency-domain HRV analysis, and echocardiography.Results: In comparison with H. pylori-negative, in all H. pylori-infected patients (n = 63) a significantly greater low frequency power, an index of sympathetic activity, and higher values of vagal tone parameters [pNN50, percentage of differences between RR intervals that are greater than 50 ms; high-frequency power in HRV analysis (HF)] were observed. The relationship between H. pylori infection and the HF value was confirmed in multi-factorial analysis. The aforementioned ANS activity differences were accompanied by: significantly fewer gastro-oesophageal acid reflux episodes, lower gastric acidity and more effective and complete oesophageal peristalsis in H. pylori-positive patients.Conclusions: H. pylori infection may affect ANS activity and via this way also contribute to gastro-oesophageal and cardiovascular pathology. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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