Dose rationale and pharmacokinetics of dexmedetomidine in mechanically ventilated new-borns: impact of design optimisation.

Purpose: There is a need for alternative analgosedatives such as dexmedetomidine in neonates. Given the ethical and practical difficulties, protocol design for clinical trials in neonates should be carefully considered before implementation. Our objective was to identify a protocol design suitable f...

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Bibliographic Details

Published in:	European Journal of Clinical Pharmacology Vol. 75; no. 10; pp. 1393 - 1405
Main Authors:	van Dijkman, Sven C., De Cock, Pieter A. J. G., Smets, Koenraad, Decaluwe, Wim, Smits, Anne, Allegaert, Karel, Vande Walle, Johan, De Paepe, Peter, Della Pasqua, Oscar
Format:	equations & formulas research tables/charts Journal Article
Published:	Springer Nature Oct2019
Online Access:	View this record in EBSCOhost