How Multiple Retrievals Affect Neural Reactivation in Young and Older Adults.
Objectives Aging can reduce the specificity with which memory episodes are represented as distributed patterns of brain activity. It remains unclear, however, whether repeated encoding and retrieval of stimuli modulate this decline. Memory repetition is thought to promote semanticization , a transfo...
| Publicado en: | Journals of Gerontology Series B: Psychological Sciences & Social Sciences Vol. 74; no. 7; pp. 1086 - 1101 |
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| Autores principales: | , |
| Formato: | Artículo |
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Oxford University Press / USA
Oct2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=138649102&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 138649102 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 10795014 JGB jtl: Journals of Gerontology Series B: Psychological Sciences & Social Sciences issn: 10795014 maglogo: N pubinfo: dt: Oct2019 vid: 74 iid: 7 pid: 622 pub: Oxford University Press / USA artinfo: ui: 138649102 10.1093/geronb/gbz075 ppf: 1086 ppct: 15 formats: tig: atl: How Multiple Retrievals Affect Neural Reactivation in Young and Older Adults. aug: au: St-Laurent, Marie Buchsbaum, Bradley R affil: Research Institute of the McGill University Health Centre, Montreal, Quebec Rotman Research Institute, Baycrest, Toronto, Ontario Department of Psychology, University of Toronto, Ontario, Canada su: Aging Memory Sensory perception Brain physiology Magnetic resonance imaging Memory in old age Latent semantic analysis sug: subj: Aging Memory Sensory perception Diagnostic Imaging Centers Brain physiology Magnetic resonance imaging Memory in old age Latent semantic analysis keyword: Episodic memory fMRI MVPA Semantic memory Episodic memory fMRI MVPA Semantic memory ab: Objectives Aging can reduce the specificity with which memory episodes are represented as distributed patterns of brain activity. It remains unclear, however, whether repeated encoding and retrieval of stimuli modulate this decline. Memory repetition is thought to promote semanticization , a transformative process during which episodic memory becomes gradually decontextualized and abstracted. Because semantic memory is considered more resilient to aging than context-rich episodic memory, we hypothesized that repeated retrieval would affect cortical reinstatement differently in young versus older adults. Methods We reanalyzed data from young and older adults undergoing functional magnetic resonance imaging while repeatedly viewing and recalling short videos. We derived trial-unique multivariate measures of similarity between video-specific brain activity patterns elicited at perception and at recall, which we compared between age groups at each repetition. Results With repetition, memory representation became gradually more distinct from perception in young adults, as reinstatement specificity converged downward toward levels observed in the older group. In older adults, alternative representations that were item-specific but orthogonal to patterns elicited at perception became more salient with repetition. Discussion Repetition transformed dominant patterns of memory representation away and orthogonally from perception in young and older adults, respectively. Although distinct, both changes are consistent with repetition-induced semanticization. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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