Structural and functional reorganization following unilateral internal capsule infarction contribute to neurological function recovery.
Purpose: To investigate proliferative reorganization in the bilateral corticospinal tract (CST) and functional reorganization in the sensorimotor network (SMN) after internal capsule stroke, and to examine the significance of this reorganization. Methods: We recruited 17 patients with first-onset ac...
| Publicado en: | Neuroradiology Vol. 61; no. 10; pp. 1181 - 1191 |
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| Autores principales: | , , , , |
| Formato: | diagnostic images pictorial research tables/charts Journal Article |
| Publicado: |
Springer Nature
Oct2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=138724896&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 138724896 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00283940 NYZ jtl: Neuroradiology issn: 00283940 maglogo: N pubinfo: dt: Oct2019 vid: 61 iid: 10 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 138724896 138724896 144052700 138724896 10.1007/s00234-019-02278-x 138724896 ppf: 1181 ppct: 10 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Structural and functional reorganization following unilateral internal capsule infarction contribute to neurological function recovery. aug: au: Lu, Qiuhong Huang, Gelun Chen, Li Li, Wenmei Liang, Zhijian affil: Department of Neurology, The First Affiliated Hospital of Guangxi Medical University & Guangxi Key Laboratory of Precision Medicine in Cardio-cerebrovascular Diseases Control and Prevention & Guangxi Clinical Research Center for Cardio-Cerebrovascular Diseases, 530021, Nanning, China sug: subj: Neural Pathways Physiology Psychomotor Performance Recovery Physiology Stroke Radiography Stroke Patients Brain Physiology Brain Anatomy and Histology Neuroradiography Male Female Adult Middle Age Magnetic Resonance Imaging Methods NIH Stroke Scale Scales Barthel Index Adult: 19-44 years Middle Aged: 45-64 years Male Female ab: Purpose: To investigate proliferative reorganization in the bilateral corticospinal tract (CST) and functional reorganization in the sensorimotor network (SMN) after internal capsule stroke, and to examine the significance of this reorganization. Methods: We recruited 17 patients with first-onset acute stroke (16 male, 1 female, mean age 52 ± 10 years) and 17 age- and sex-matched healthy controls. We excluded patients aged < 18 or > 65 years and those with lesions outside the unilateral internal capsule. All subjects underwent diffusion tensor imaging and resting-state functional MRI on days 7, 30, and 90 from symptom onset. We measured fractional anisotropy (FA) in the CST, interhemispheric functional connectivity (FC) within the SMN, and pre-MRI clinical scores, including the National Institutes of Health Stroke Scale (NIHSS), Barthel Index (BI), and Fugl–Meyer (FM). Correlations among the changes in FA, FC, and clinical scores were analyzed. Results: From day 7 to 90 after stroke, FA in the bilateral CST increased (ipsilesional side, Pinternal capsule = 0.009, Pcentrum semiovale = 0.001; contralesional side, Pinternal capsule = 0.006, Pcentrum semiovale = 0.017), as did FC (P < 0.05); NIHSS scores decreased (P < 0.05), while FM and BI progressively increased (P < 0.05). Increased FA in bilateral CST was negatively correlated with decreased NIHSS scores. Increased FA in only the ipsilesional side was positively correlated with increased FM. Increased FC was positively correlated only with increased BI. Conclusion: Proliferative reorganization in the CST and functional reorganization in the SMN support and promote neurological functional recovery after internal capsule infarction. pubtype: Academic Journal doctype: diagnostic images pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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