Studies of 13C-urea breath test for diagnosis of Helicobacter pylori infection in Japan.
In recent years Helicobacter pylori infection has been implicated in the etiology of a variety of upper gastrointestinal diseases. The aim of this multi-center trial was to search for the cut-off value of the simple 13C-urea breath test (13C-UBT) for diagnosis of H. pylori infection, and to examine...
| Publicado en: | Journal of Gastroenterology Vol. 33; no. 1; pp. 6 - 14 |
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| Autores principales: | , , , |
| Formato: | clinical trial research Journal Article |
| Publicado: |
Springer Nature
1998
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=138750365&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 138750365 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09441174 EJ7 jtl: Journal of Gastroenterology issn: 09441174 maglogo: N pubinfo: dt: 1998 vid: 33 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 138750365 138750365 NLM9497214 138750365 10.1007/pl00009968 NLM9497214 138750365 ppf: 6 ppct: 8 formats: tig: atl: Studies of 13C-urea breath test for diagnosis of Helicobacter pylori infection in Japan. aug: au: Ohara, S Kato, M Asaka, M Toyota, T affil: C-13UBT Study Group, Third Department of Internal Medicine, Tohoku University School of Medicine, Miyagi, Japan sug: subj: Urea Metabolism Helicobacter Infections Diagnosis Helicobacter Pylori Gastrointestinal Diseases Diagnosis Breath Tests Methods Gastrointestinal Diseases Microbiology Helicobacter Infections Urease Metabolism Female Helicobacter Infections Microbiology Male Japan Middle Age Aged Human Gastrointestinal Diseases Endoscopy, Gastrointestinal Adult Isotopes Clinical Trials Validation Studies Comparative Studies Evaluation Research Multicenter Studies Middle Aged: 45-64 years Aged: 65+ years Adult: 19-44 years Female Male ab: In recent years Helicobacter pylori infection has been implicated in the etiology of a variety of upper gastrointestinal diseases. The aim of this multi-center trial was to search for the cut-off value of the simple 13C-urea breath test (13C-UBT) for diagnosis of H. pylori infection, and to examine the sensitivity and specificity of 13C-UBT for culture, the rapid urease test (CLO test), histology, and serological tests. Two hundred and forty-eight patients participated in this study after giving their informed consent. Endoscopic biopsy specimens were taken from gastric antrum and corpus for culture (190 patients), CLO test (222 patients), and histology (98 patients). A serological test was carried out for all patients. H. pylori infection was established when culture was positive or more than two of the tests, histology, CLO test, and serological test, were positive, and non-infection status was established when the all tests more than two tests were negative. After baseline breath samples were taken, the patients (who had fasted) were given 100mg of 13C-urea in 100ml water while sitting; they washed out the mouth with water. They were then placed in the left lateral decubitus position for 5 min, and additional breath samples were taken 10, 20, 30, 45, and 60 min after urea administration, with patients in the sitting position. One hundred and sixty-five of the 248 patients were infected, 48 were not infected, and H. pylori infection status was not evaluated in 35 by endoscopic and serological tests. Breath samples at 20 min were employed to determine the cut-off value. Using the receiver operating characteristic (ROC) curve, we determined the cut-off value for a positive UBT at 2.5 delta per thousand. The sensitivities of UBT for culture, CLO test, histology, and serological test were 98.4%, 98.6%, 100.0%, and 92.5%, and the specificities were 78.8%, 82.5%, 83.3%, and 87.3%, respectively. The cut-off value of 13C-UBT for the diagnosis of H. pylori infection was 2.5 delta per thousand; this test is a simple and noninvasive method for the diagnosis of this infection and has high sensitivity and specificity. pubtype: Academic Journal doctype: clinical trial research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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