Cancer-Testis Antigens: A Novel Group of Tumor Biomarkers in Ovarian Cancers.
Context: Ovarian cancer is the most fatal gynecological malignancy with no effective screening strategy for early detection. As most cases are being detected in advance stages, conventional therapies are not beneficial for the majority of patients. Cancer-testis antigens (CTAs) are a group of tumor...
| Publicado en: | Iranian Journal of Cancer Prevention Vol. 9; no. 6; pp. 1 - 15 |
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| Autores principales: | , , , , , |
| Formato: | review tables/charts Journal Article |
| Publicado: |
Medical Journals Commission of the Ministry of Health & Medical Education
Dec2016
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=138820149&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 138820149 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 20082398 BCLH jtl: Iranian Journal of Cancer Prevention issn: 20082398 maglogo: N pubinfo: dt: Dec2016 vid: 9 iid: 6 pid: 66482 pub: Medical Journals Commission of the Ministry of Health & Medical Education artinfo: ui: 138820149 138820149 138820149 10.17795/ijcp-4993 138820149 ppf: 1 ppct: 14 formats: fmt: @attributes: type: P tig: atl: Cancer-Testis Antigens: A Novel Group of Tumor Biomarkers in Ovarian Cancers. aug: au: Taherian-Esfahani, Zahra Abedin-Do, Atieh Nikpayam, Elahe Tasharofi, Behnoosh Nezamabadi, Akram Ghahghaei Ghafouri-Fard, Soudeh affil: Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran sug: subj: Tumor Markers, Biological Ovarian Neoplasms Antigens, Tumor Immunotherapy Gene Expression ab: Context: Ovarian cancer is the most fatal gynecological malignancy with no effective screening strategy for early detection. As most cases are being detected in advance stages, conventional therapies are not beneficial for the majority of patients. Cancer-testis antigens (CTAs) are a group of tumor associated antigens with specific expression pattern in cancers which potentiate them for application as cancer biomarkers and targets for immunotherapy. Evidence Acquisition: We performed a computerized search of the MEDLINE/PUBMED databases with key words: ovarian cancer, cancer-testis antigen, biomarker and immunotherapy. Results: Thirty five CTAs have been shown to be expressed in ovarian cancer. At least 13 of them have been shown to elicit immune responses in different studies. The pattern of expression for some of them may facilitate molecular classification of different histologic classes of ovarian cancer. In addition, some CTAs such as NY-ESO-1 and MAGE have been used as targets for immunotherapeutic approaches with promising results. Conclusions: The expression pattern of CTAs in ovarian cancer and the preliminary results of clinical trials indicate that CTAs can be used as targets for immunotherapy of ovarian cancer patients. pubtype: Academic Journal doctype: review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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