Adenosine Deaminase Activity in Chronic Lymphocytic Leukemia and Healthy Subjects.
Background: B cell chronic lymphocytic leukemia is one of the most frequent hematologic malignancies in the world. Cellular surface CD markers and serum Beta-2-microglobulin may be used as a prognostic tool in CLL patients. Objectives: In the present study we introduce serum adenosine deaminase as a...
| Publicado en: | Iranian Journal of Cancer Prevention Vol. 9; no. 3; pp. 1 - 7 |
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| Autores principales: | , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Medical Journals Commission of the Ministry of Health & Medical Education
Jun2016
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=138824594&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 138824594 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 20082398 BCLH jtl: Iranian Journal of Cancer Prevention issn: 20082398 maglogo: N pubinfo: dt: Jun2016 vid: 9 iid: 3 pid: 66482 pub: Medical Journals Commission of the Ministry of Health & Medical Education artinfo: ui: 138824594 138824594 138824594 10.17795/ijcp-5069 138824594 ppf: 1 ppct: 6 formats: fmt: @attributes: type: P tig: atl: Adenosine Deaminase Activity in Chronic Lymphocytic Leukemia and Healthy Subjects. aug: au: Ghaderi, Bayazid Amini, Sabrieh Maroofi, Farzad Jalali, Chiya Javanmardi, Mitra Roshani, Daem Abdi, Mohammad affil: Department of Internal Medicine, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, IR Iran sug: subj: Leukemia, Lymphocytic, Chronic Diagnosis Hydrolases Blood Tumor Markers, Biological Blood Human Blood Specimen Collection Leukocyte Count Erythrocyte Count Platelet Count Blood Sedimentation Serum Globulins Lactate Dehydrogenase Comparative Studies Leukemia, Lymphocytic, Chronic Blood Descriptive Statistics Sensitivity and Specificity Predictive Validity ab: Background: B cell chronic lymphocytic leukemia is one of the most frequent hematologic malignancies in the world. Cellular surface CD markers and serum Beta-2-microglobulin may be used as a prognostic tool in CLL patients. Objectives: In the present study we introduce serum adenosine deaminase as a diagnostic marker in CLL. Materials and Methods: Blood samples were collected from B-CLL and healthy subjects. White blood cell, red blood cell and platelet count and blood Erythrocyte sedimentation rate was recorded and serum Beta-2-microglobulin, Lactate dehydrogenase and total ADA enzyme activity were determined. Results: Serum ADA activity was significantly higher in patients group than that of controls. ADA had a significant and direct correlation with B2M, WBC, LDH and ESR. However, there was not any relation between ADA and the stages of disease. Diagnostic cut-off, sensitivity and specificity of the serum ADA test were 27.97 U/L, 91% and 94%, respectively. Conclusions: A higher ADA activity in patients group and its correlation with CLL markers were seen in our study. High diagnostic value of serum ADA in our study suggests that it might be considered as a useful screening tool among the other markers in CLL. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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