Calcium Fluxes in Work-Related Muscle Disorder: Implications from a Rat Model.
Introduction. Ca2+ regulatory excitation-contraction coupling properties are key topics of interest in the development of work-related muscle myalgia and may constitute an underlying cause of muscle pain and loss of force generating capacity. Method. A well-established rat model of high repetition h...
| Publicado en: | BioMed Research International pp. 1 - 15 |
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| Autores principales: | , , , , , , , |
| Formato: | equations & formulas pictorial research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
9/30/2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=138877810&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 138877810 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23146133 FT2T jtl: BioMed Research International issn: 23146133 maglogo: N pubinfo: dt: 9/30/2019 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 138877810 138877810 138877810 10.1155/2019/5040818 138877810 ppf: 1 ppct: 14 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Calcium Fluxes in Work-Related Muscle Disorder: Implications from a Rat Model. aug: au: Hadrevi, J. Barbe, M. F. Ørtenblad, N. Frandsen, U. Boyle, E. Lazar, S. Sjøgaard, G. Søgaard, K. affil: Department of Public Health and Clinical Medicines, Occupational and Environmental Medicine, Umeå University, 901 87 Umeå, Sweden sug: subj: Task Performance and Analysis Methods Calcium Analysis Membrane Transport Proteins Analysis Cytoplasm Analysis Occupational Diseases Risk Factors Muscle Pain Risk Factors Animal Studies Rats Muscle Fatigue Alkaloids Calcium Binding Proteins Muscle, Skeletal Gene Expression ab: Introduction. Ca2+ regulatory excitation-contraction coupling properties are key topics of interest in the development of work-related muscle myalgia and may constitute an underlying cause of muscle pain and loss of force generating capacity. Method. A well-established rat model of high repetition high force (HRHF) work was used to investigate if such exposure leads to an increase in cytosolic Ca2+ concentration ([Ca2+]i) and changes in sarcoplasmic reticulum (SR) vesicle Ca2+ uptake and release rates. Result. Six weeks exposure of rats to HRHF increased indicators of fatigue, pain behaviors, and [Ca2+]i, the latter implied by around 50–100% increases in pCam, as well as in the Ca2+ handling proteins RyR1 and Casq1 accompanied by an ∼10% increased SR Ca2+ uptake rate in extensor and flexor muscles compared to those of control rats. This demonstrated a work-related altered myocellular Ca2+ regulation, SR Ca2+ handling, and SR protein expression. Discussion. These disturbances may mirror intracellular changes in early stages of human work-related myalgic muscle. Increased uptake of Ca2+ into the SR may reflect an early adaptation to avoid a sustained detrimental increase in [Ca2+]i similar to the previous findings of deteriorated Ca2+ regulation and impaired function in fatigued human muscle. pubtype: Academic Journal doctype: equations & formulas pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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