Cerebral Metabolites on the Descending Limb of Acute Alcohol: A Preliminary 1H MRS Study.
Aims Chronic alcohol use is associated with cerebral metabolite abnormalities, yet alcohol's acute effects on neurometabolism are not well understood. This preliminary study investigated cerebral metabolite changes in vivo on the descending limb of blood alcohol in healthy moderate drinkers. Methods...
| Publicado en: | Alcohol & Alcoholism Vol. 54; no. 5; pp. 487 - 497 |
|---|---|
| Autores principales: | , , , , , , |
| Formato: | diagnostic images research tables/charts tracings Journal Article |
| Publicado: |
Oxford University Press / USA
Sep2019
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=138895496&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 138895496 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 07350414 FA3 jtl: Alcohol & Alcoholism issn: 07350414 maglogo: N pubinfo: dt: Sep2019 vid: 54 iid: 5 pid: 622 pub: Oxford University Press / USA artinfo: ui: 138895496 138895496 138895496 10.1093/alcalc/agz062 138895496 ppf: 487 ppct: 10 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Cerebral Metabolites on the Descending Limb of Acute Alcohol: A Preliminary 1H MRS Study. aug: au: Monnig, Mollie A Woods, Adam J Walsh, Edward Martone, Christina M Blumenthal, Jonah Monti, Peter M Cohen, Ronald A affil: Center for Alcohol and Addiction Studies, Brown University, Providence, RI, USA sug: subj: Alcohol Abuse Complications Brain Metabolism Metabolites Alcohols Metabolism Human Pretest-Posttest Design Magnetic Resonance Imaging Thalamus White Matter Breath Tests Descriptive Statistics ab: Aims Chronic alcohol use is associated with cerebral metabolite abnormalities, yet alcohol's acute effects on neurometabolism are not well understood. This preliminary study investigated cerebral metabolite changes in vivo on the descending limb of blood alcohol in healthy moderate drinkers. Methods In a pre/post design, participants (N = 13) completed magnetic resonance imaging (MRI) scans prior to and approximately 5 hours after consuming a moderate dose of alcohol (0.60 grams alcohol per kilogram of body weight). Magnetic resonance spectroscopy (1H MRS) was used to quantify cerebral metabolites related to glutamatergic transmission (Glx) and neuroimmune activity (Cho, GSH, myo-inositol) in the thalamus and frontal white matter. Results Breath alcohol concentration (BrAC) peaked at 0.070±0.008% (mean ± standard deviation) and averaged 0.025±0.011% directly prior to the descending limb scan. In the thalamus, Glx/Cr and Cho/Cr were significantly elevated on the descending limb scan relative to baseline. BrAC area under the curve, an index of alcohol exposure during the session, was significantly, positively associated with levels of Glx/Cr, Cho/Cr and GSH/Cr in the thalamus. GSH/Cr on the descending limb was inversely correlated with subjective alcohol sedation. Conclusions This study offers preliminary evidence of alcohol-related increases in Glx/Cr, Cho/Cr and GSH/Cr on the descending limb of blood alcohol concentration. Findings add novel information to previous research on neurometabolic changes at peak blood alcohol in healthy individuals and during withdrawal in individuals with alcohol use disorder. pubtype: Academic Journal doctype: diagnostic images research tables/charts tracings Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|