Effects of Thyroid Hormone Treatment on Diaphragmatic Efficiency in Mechanically Ventilated Subjects With Nonthyroidal Illness Syndrome.
BACKGROUND: Several respiratory abnormalities can be present in primary hypothyroidism and can be reversed with adequate hormone treatment. However, the role of thyroid hormone replacement therapy on the respiratory system in patients with nonthyroidal illness syndrome is still unclear. This physiol...
| Publicado en: | Respiratory Care Vol. 64; no. 10; pp. 1199 - 1208 |
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| Autores principales: | , , , , , , , , , , , , |
| Formato: | CEU research tables/charts Journal Article |
| Publicado: |
Mary Ann Liebert, Inc.
Oct2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=138957774&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 138957774 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00201324 4GG jtl: Respiratory Care issn: 00201324 maglogo: N pubinfo: dt: Oct2019 vid: 64 iid: 10 pid: 1365 pub: Mary Ann Liebert, Inc. place: New Rochelle, New York artinfo: ui: 138957774 138957774 138957774 10.4187/respcare.06770 138957774 ppf: 1199 ppct: 9 formats: fmt: @attributes: type: P tig: atl: Effects of Thyroid Hormone Treatment on Diaphragmatic Efficiency in Mechanically Ventilated Subjects With Nonthyroidal Illness Syndrome. aug: au: Bello, Giuseppe Spinazzola, Giorgia Giammatteo, Valentina Montini, Luca De Pascale, Gennaro Bisanti, Alessandra Annetta, Maria G. Troiani, Eliana Bianchi, Antonio Pontecorvi, Alfredo Pennisi, Mariano A. Conti, Giorgio Antonelli, Massimo affil: Dipartimento di Scienze dell'Emergenza, Anestesiologiche e della Rianimazione, 00168 Rome, Italy sug: subj: Thyroid Hormones Pharmacodynamics Diaphragm Physiology Respiration, Artificial Ventilator Patients Thyroid Diseases Drug Therapy Treatment Outcomes Human Education, Continuing (Credit) Triiodothyronine Administration and Dosage Administration, Intravenous Perfusion Airway Pressure Triiodothyronine Blood Water Descriptive Statistics One-Way Analysis of Variance Data Analysis Software Male Female Middle Age Aged Italy Middle Aged: 45-64 years Aged: 65+ years Male Female ab: BACKGROUND: Several respiratory abnormalities can be present in primary hypothyroidism and can be reversed with adequate hormone treatment. However, the role of thyroid hormone replacement therapy on the respiratory system in patients with nonthyroidal illness syndrome is still unclear. This physiologic study evaluated the effect of thyroid hormone treatment on respiratory muscle function in subjects with nonthyroidal illness syndrome and while on mechanical ventilation. The primary end point was neuromechanical efficiency, which provides an estimate of the efficiency of diaphragmatic contraction. Secondary end points were the transdiaphragmatic pressure-time product and the swing of the electrical activity of the diaphragm, which reflect the work of breathing and inspiratory effort, respectively. METHODS: Fifteen subjects on mechanical ventilation for ≥48 h and with a diagnosis of nonthyroidal illness syndrome who had a failed spontaneous breathing trial, received intravenous triiodothyronine. The hormone was administered as an intravenous bolus of 0.4 µg/kg triiodothyronine, followed by continuous perfusion at 0.6 µg/kg for 24 h. Neuromechanical efficiency was calculated as the ratio between the drop in airway pressure during an expiratory occlusion and the corresponding electrical activity of the diaphragm peak. Recordings were taken at baseline and after 3, 6, and 24 h. RESULTS: After study completion, free triiodothyronine serum concentrations increased in all the subjects (mean ± SD increase, 0.84 ± 0.34 pg/mL). Neuromechanical efficiency showed no significant changes throughout the study (mean ± SD baseline, 1.40 ± 0.87 cm H2O/µV; 3 h, 1.28 ± 0.64 cm H2O/µV; 6 h, 1.33 ± 0.87 cm H2O/µV; 24 h, 1.41 ± 0.96 cm H2O/µV). Similarly, no variations in transdiaphragmatic pressure-time product per min (mean ± SD baseline, 238.1 ± 124 cm H2O x s/min; 3 h, 242.5 ± 140.3 cm H2O x s /min; 6 h, 247.5 ± 161.7 cm H2O x s/min; 24 h, 281.2 ± 201.2 cm H2O x s/min) or swing of electrical activity of the diaphragm (mean ± baseline, 20.9 ± 13.1 µ V; 3 h, 17.2 ± 8.3 µV; 6 h, 17.4 ± 11.3 µV; 24 h, 20.3 ± 13.7 µV) were observed during hormone administration. CONCLUSIONS: In the subjects on mechanical ventilation who were admitted to the ICU with nonthyroidal illness syndrome, thyroid hormone replacement treatment did not yield any benefit on respiratory muscle function when assessed by neuromechanical efficiency, which indicated that, in these subjects restoring normal levels of serum thyroid hormones is debatable. (ClinicalTrials.gov registration NCT03157466.) pubtype: Academic Journal doctype: CEU research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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