Temperature Depth Profiles Induced in Human Skin In Vivo Using Pulsed 975 nm Irradiation.
Background and Objectives: The aim of this study was to determine the temperature depth profiles induced in human skin in vivo by using a pulsed 975 nm diode laser (with 5 ms pulse duration) and compare them with those induced by the more common 532 nm (KTP) and 1,064 nm (Nd:YAG) lasers. Quantitativ...
| Published in: | Lasers in Surgery & Medicine Vol. 51; no. 9; pp. 774 - 785 |
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| Main Authors: | , , , , , |
| Format: | research Journal Article |
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Wiley-Blackwell
Nov2019
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=138991396&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 138991396 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01968092 OCY jtl: Lasers in Surgery & Medicine issn: 01968092 maglogo: Y pubinfo: dt: Nov2019 vid: 51 iid: 9 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 138991396 138991396 NLM31194264 138991396 10.1002/lsm.23108 NLM31194264 138991396 ppf: 774 ppct: 11 formats: tig: atl: Temperature Depth Profiles Induced in Human Skin In Vivo Using Pulsed 975 nm Irradiation. aug: au: Milanic, Matija Cenian, Adam Verdel, Nina Cenian, Witold Stergar, Jost Majaron, Boris affil: Department of Physics, Faculty of Mathematics and Physics, University of Ljubljana, Jadranska 21, Ljubljana Slovenia sug: subj: Heat Lasers Skin Radiation Effects Middle Age Human Female Adult Male Validation Studies Comparative Studies Evaluation Research Multicenter Studies Middle Aged: 45-64 years Adult: 19-44 years Female Male ab: Background and Objectives: The aim of this study was to determine the temperature depth profiles induced in human skin in vivo by using a pulsed 975 nm diode laser (with 5 ms pulse duration) and compare them with those induced by the more common 532 nm (KTP) and 1,064 nm (Nd:YAG) lasers. Quantitative assessment of the energy deposition characteristics in human skin at 975 nm should help design of safe and effective treatment protocols when using such lasers.Study Design/materials and Methods: Temperature depth profiles induced in the human skin by the three lasers were determined using pulsed photothermal radiometry (PPTR). This technique involves time-resolved measurement of mid-infrared emission from the irradiated test site and reconstruction of the laser-induced temperature profiles using an earlier developed optimization algorithm. Measurements were performed on volar sides of the forearms in seven volunteers with healthy skin. At irradiation spot diameters of 3-4 mm, the radiant exposures were 0.24, 0.36, and 5.7 J/cm2 for the 975, 532, and 1,064 nm lasers, respectively.Results: Upon normalization to the same radiant exposure of 1 J/cm 2 , the assessed maximum temperature rise in the epidermis averaged 0.8 °C for the 975 nm laser, 7.4 °C for the 532 nm, and 0.6 °C for the 1,064 nm laser. The characteristic subsurface depth to which 50% of the absorbed laser energy was deposited was on average 0.31 mm at 975 nm irradiation, and slightly deeper at 1,064 nm, and 0.15 mm at 532 nm. The experimentally obtained relations were reproduced in a dedicated numerical simulation.Conclusions: The assessed energy deposition characteristics show that the pulsed 975 nm diode laser is very suitable for controlled heating of the upper dermis as required, for example, for nonablative skin rejuvenation. The risks of nonselective overheating of the epidermis and subcutis are significantly reduced in comparison with irradiation at 532 and 1,064 nm, respectively. Lasers Surg. Med. © 2019 Wiley Periodicals, Inc. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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